Bohets H - Search Results

1

Identification of the cytochrome P450 enzymes involved in the metabolism of cisapride: in vitro studies of potential co-medication interactions.

Bohets H, Lavrijsen K, Hendrickx J, van Houdt J, van Genechten V, Verboven P, Meuldermans W, Heykants J. Bohets H, et al. Br J Pharmacol. 2000 Apr;129(8):1655-67. doi: 10.1038/sj.bjp.0703246. Br J Pharmacol. 2000. PMID: 10780971 Free PMC article.

2

Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans.

Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M. Paulussen A, et al. Among authors: bohets h. Pharmacogenetics. 2000 Jul;10(5):415-24. doi: 10.1097/00008571-200007000-00005. Pharmacogenetics. 2000. PMID: 10898111

3

Strategies for absorption screening in drug discovery and development.

Bohets H, Annaert P, Mannens G, Van Beijsterveldt L, Anciaux K, Verboven P, Meuldermans W, Lavrijsen K. Bohets H, et al. Curr Top Med Chem. 2001 Nov;1(5):367-83. doi: 10.2174/1568026013394886. Curr Top Med Chem. 2001. PMID: 11899103 Review.

4

Rapid permeability screening in drug discovery to predict human intestinal absorption.

Mannens GS, Bohets H, Verboven P, Steemans K, Lavrijsen K, Meuldermans W. Mannens GS, et al. Among authors: bohets h. Ernst Schering Res Found Workshop. 2002;(37):49-67. doi: 10.1007/978-3-662-04383-7_3. Ernst Schering Res Found Workshop. 2002. PMID: 11975200 Review. No abstract available.

5

Fast monolithic micellar liquid chromatography: an alternative drug permeability assessing method for high-throughput screening.

Detroyer A, Stokbroekx S, Bohets H, Lorreyne W, Timmerman P, Verboven P, Massart DL, Vander Heyden Y. Detroyer A, et al. Among authors: bohets h. Anal Chem. 2004 Dec 15;76(24):7304-9. doi: 10.1021/ac048944k. Anal Chem. 2004. PMID: 15595873

6

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes.

Bahadur N, Leathart JB, Mutch E, Steimel-Crespi D, Dunn SA, Gilissen R, Houdt JV, Hendrickx J, Mannens G, Bohets H, Williams FM, Armstrong M, Crespi CL, Daly AK. Bahadur N, et al. Among authors: bohets h. Biochem Pharmacol. 2002 Dec 1;64(11):1579-89. doi: 10.1016/s0006-2952(02)01354-0. Biochem Pharmacol. 2002. PMID: 12429347

7

Clinical pharmacology of alcaftadine, a novel antihistamine for the prevention of allergic conjunctivitis.

Bohets H, McGowan C, Mannens G, Schroeder N, Edwards-Swanson K, Shapiro A. Bohets H, et al. J Ocul Pharmacol Ther. 2011 Apr;27(2):187-95. doi: 10.1089/jop.2010.0153. Epub 2011 Feb 12. J Ocul Pharmacol Ther. 2011. PMID: 21314437 Clinical Trial.

8

The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis.

Vanden Bossche H, Ausma J, Bohets H, Vermuyten K, Willemsens G, Marichal P, Meerpoel L, Odds F, Borgers M. Vanden Bossche H, et al. Among authors: bohets h. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8. doi: 10.1128/AAC.48.9.3272-3278.2004. Antimicrob Agents Chemother. 2004. PMID: 15328084 Free PMC article.

9

In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

Janssen PA, Lewi PJ, Arnold E, Daeyaert F, de Jonge M, Heeres J, Koymans L, Vinkers M, Guillemont J, Pasquier E, Kukla M, Ludovici D, Andries K, de Béthune MP, Pauwels R, Das K, Clark AD Jr, Frenkel YV, Hughes SH, Medaer B, De Knaep F, Bohets H, De Clerck F, Lampo A, Williams P, Stoffels P. Janssen PA, et al. Among authors: bohets h. J Med Chem. 2005 Mar 24;48(6):1901-9. doi: 10.1021/jm040840e. J Med Chem. 2005. PMID: 15771434 Review.

10

Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds.

Lewi P, Arnold E, Andries K, Bohets H, Borghys H, Clark A, Daeyaert F, Das K, de Béthune MP, de Jonge M, Heeres J, Koymans L, Leempoels J, Peeters J, Timmerman P, Van den Broeck W, Vanhoutte F, Van't Klooster G, Vinkers M, Volovik Y, Janssen PA. Lewi P, et al. Among authors: bohets h. Drugs R D. 2004;5(5):245-57. doi: 10.2165/00126839-200405050-00001. Drugs R D. 2004. PMID: 15357624

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