ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding.
Gong GQ, Masson GR, Lee WJ, Dickson JMJ, Kendall JD, Rathinaswamy MK, Buchanan CM, Middleditch M, Owen BM, Spicer JA, Rewcastle GW, Denny WA, Burke JE, Shepherd PR, Williams RL, Flanagan JU.
Gong GQ, et al. Among authors: flanagan ju.
Biochem J. 2024 Dec 4;481(23):1787-1802. doi: 10.1042/BCJ20240479.
Biochem J. 2024.
PMID: 39485310