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(S)-4-Methyl-2-(methylamino)pentanoic acid [4, 4-bis(4-fluorophenyl)butyl]amide hydrochloride, a novel calcium channel antagonist, is efficacious in several animal models of pain.
Song Y, Bowersox SS, Connor DT, Dooley DJ, Lotarski SM, Malone T, Miljanich G, Millerman E, Rafferty MF, Rock D, Roth BD, Schmidt J, Stoehr S, Szoke BG, Taylor C, Vartanian M, Wang YX. Song Y, et al. Among authors: malone t. J Med Chem. 2000 Sep 21;43(19):3474-7. doi: 10.1021/jm000134n. J Med Chem. 2000. PMID: 11000000 No abstract available.
Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity.
Bigge CF, Malone TC, Boxer PA, Nelson CB, Ortwine DF, Schelkun RM, Retz DM, Lescosky LJ, Borosky SA, Vartanian MG, et al. Bigge CF, et al. Among authors: malone tc. J Med Chem. 1995 Sep 15;38(19):3720-40. doi: 10.1021/jm00019a003. J Med Chem. 1995. PMID: 7562904
233 results