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Independent confirmation of a major locus for obesity on chromosome 10.
Hinney A, Ziegler A, Oeffner F, Wedewardt C, Vogel M, Wulftange H, Geller F, Stübing K, Siegfried W, Goldschmidt HP, Remschmidt H, Hebebrand J. Hinney A, et al. Among authors: siegfried w. J Clin Endocrinol Metab. 2000 Aug;85(8):2962-5. doi: 10.1210/jcem.85.8.6852. J Clin Endocrinol Metab. 2000. PMID: 10946912
Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity.
Hinney A, Hohmann S, Geller F, Vogel C, Hess C, Wermter AK, Brokamp B, Goldschmidt H, Siegfried W, Remschmidt H, Schäfer H, Gudermann T, Hebebrand J. Hinney A, et al. Among authors: siegfried w. J Clin Endocrinol Metab. 2003 Sep;88(9):4258-67. doi: 10.1210/jc.2003-030233. J Clin Endocrinol Metab. 2003. PMID: 12970296 Free article. Clinical Trial.
Systematic mutation screening of the pro-opiomelanocortin gene: identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes.
Hinney A, Becker I, Heibült O, Nottebom K, Schmidt A, Ziegler A, Mayer H, Siegfried W, Blum WF, Remschmidt H, Hebebrand J. Hinney A, et al. Among authors: siegfried w. J Clin Endocrinol Metab. 1998 Oct;83(10):3737-41. doi: 10.1210/jcem.83.10.5298. J Clin Endocrinol Metab. 1998. PMID: 9768693
Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans.
Hinney A, Schmidt A, Nottebom K, Heibült O, Becker I, Ziegler A, Gerber G, Sina M, Görg T, Mayer H, Siegfried W, Fichter M, Remschmidt H, Hebebrand J. Hinney A, et al. Among authors: siegfried w. J Clin Endocrinol Metab. 1999 Apr;84(4):1483-6. doi: 10.1210/jcem.84.4.5728. J Clin Endocrinol Metab. 1999. PMID: 10199800
79 results