ANG II is a mitogen for a murine cell line isolated from medullary thick ascending limb of Henle's loop.
Wolf G, Ziyadeh FN, Helmchen U, Zahner G, Schroeder R, Stahl RA.
Wolf G, et al.
Am J Physiol. 1995 May;268(5 Pt 2):F940-7. doi: 10.1152/ajprenal.1995.268.5.F940.
Am J Physiol. 1995.
PMID: 7771522
This observation is in striking contrast to syngeneic proximal tubular cells in which it was previously shown that the peptide induced cellular hypertrophy and slightly inhibited proliferation [G. Wolf and E. G. Neilson. Am. J. Physiol. 259 (Renal Fluid Elect …
This observation is in striking contrast to syngeneic proximal tubular cells in which it was previously shown that the peptide induced cellu …