Clark RF - Search Results

1

Synthesis of 2-fluoro-6-O-propargyl-11,12-carbamate ketolides. A novel class of antibiotics.

Phan LT, Clark RF, Rupp M, Or YS, Chu DT, Ma Z. Phan LT, et al. Among authors: clark rf. Org Lett. 2000 Sep 21;2(19):2951-4. doi: 10.1021/ol006226o. Org Lett. 2000. PMID: 10986080

2

Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.

Or YS, Clark RF, Wang S, Chu DT, Nilius AM, Flamm RK, Mitten M, Ewing P, Alder J, Ma Z. Or YS, et al. Among authors: clark rf. J Med Chem. 2000 Mar 23;43(6):1045-9. doi: 10.1021/jm990618n. J Med Chem. 2000. PMID: 10737737 No abstract available.

3

Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives.

Clark RF, Ma Z, Wang S, Griesgraber G, Tufano M, Yong H, Li L, Zhang X, Nilius AM, Chu DT, Or YS. Clark RF, et al. Bioorg Med Chem Lett. 2000 Apr 17;10(8):815-9. doi: 10.1016/s0960-894x(00)00106-2. Bioorg Med Chem Lett. 2000. PMID: 10782693

4

Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.

Ma Z, Clark RF, Brazzale A, Wang S, Rupp MJ, Li L, Griesgraber G, Zhang S, Yong H, Phan LT, Nemoto PA, Chu DT, Plattner JJ, Zhang X, Zhong P, Cao Z, Nilius AM, Shortridge VD, Flamm R, Mitten M, Meulbroek J, Ewing P, Alder J, Or YS. Ma Z, et al. Among authors: clark rf. J Med Chem. 2001 Nov 22;44(24):4137-56. doi: 10.1021/jm0102349. J Med Chem. 2001. PMID: 11708916

5

Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.

Yong H, Gu YG, Clark RF, Marron T, Ma Z, Soni N, Stone GG, Nilius AM, Marsh K, Djuric SW. Yong H, et al. Among authors: clark rf. Bioorg Med Chem Lett. 2005 May 16;15(10):2653-8. doi: 10.1016/j.bmcl.2005.03.011. Bioorg Med Chem Lett. 2005. PMID: 15863336

6

Improvements in the minimum binding sequence of C5a: examination of His-67.

Or YS, Clark RF, Lane B, Mollison KW, Carter GW, Luly JR. Or YS, et al. Among authors: clark rf. J Med Chem. 1992 Jan 24;35(2):402-6. doi: 10.1021/jm00080a030. J Med Chem. 1992. PMID: 1732557 No abstract available.

7

Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases.

Mollison KW, Fey TA, Gauvin DM, Sheets MP, Smith ML, Pong M, Krause R, Miller L, Or YS, Kawai M, Wagner R, Wiedeman PE, Clark RF, Gunawardana IW, Rhoades TA, Henry CL, Tu NP, BaMaung NY, Kopecka H, Liu L, Xie Q, Lane BC, Trevillyan JM, Marsh K, Luly JR, et al. Mollison KW, et al. Among authors: clark rf. Curr Pharm Des. 1998 Oct;4(5):367-79. Curr Pharm Des. 1998. PMID: 10197049 Review.

8

Novel inhibitors of bacterial protein synthesis: structure-activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants.

Clark RF, Wang S, Ma Z, Weitzberg M, Motter C, Tufano M, Wagner R, Gu YG, Dandliker PJ, Lerner CG, Chovan LE, Cai Y, Black-Schaefer CL, Lynch L, Kalvin D, Nilius AM, Pratt SD, Soni N, Zhang T, Zhang X, Beutel BA. Clark RF, et al. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3299-302. doi: 10.1016/j.bmcl.2004.03.091. Bioorg Med Chem Lett. 2004. PMID: 15149694

9

Novel antibacterial class.

Dandliker PJ, Pratt SD, Nilius AM, Black-Schaefer C, Ruan X, Towne DL, Clark RF, Englund EE, Wagner R, Weitzberg M, Chovan LE, Hickman RK, Daly MM, Kakavas S, Zhong P, Cao Z, David CA, Xuei X, Lerner CG, Soni NB, Bui M, Shen LL, Cai Y, Merta PJ, Saiki AY, Beutel BA. Dandliker PJ, et al. Among authors: clark rf. Antimicrob Agents Chemother. 2003 Dec;47(12):3831-9. doi: 10.1128/AAC.47.12.3831-3839.2003. Antimicrob Agents Chemother. 2003. PMID: 14638491 Free PMC article.

10

Structure-activity relationships of novel potent MurF inhibitors.

Gu YG, Florjancic AS, Clark RF, Zhang T, Cooper CS, Anderson DD, Lerner CG, McCall JO, Cai Y, Black-Schaefer CL, Stamper GF, Hajduk PJ, Beutel BA. Gu YG, et al. Among authors: clark rf. Bioorg Med Chem Lett. 2004 Jan 5;14(1):267-70. doi: 10.1016/j.bmcl.2003.09.073. Bioorg Med Chem Lett. 2004. PMID: 14684340

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