Phan LT - Search Results

1

Synthesis of 2-fluoro-6-O-propargyl-11,12-carbamate ketolides. A novel class of antibiotics.

Phan LT, Clark RF, Rupp M, Or YS, Chu DT, Ma Z. Phan LT, et al. Org Lett. 2000 Sep 21;2(19):2951-4. doi: 10.1021/ol006226o. Org Lett. 2000. PMID: 10986080

2

Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.

Ma Z, Clark RF, Brazzale A, Wang S, Rupp MJ, Li L, Griesgraber G, Zhang S, Yong H, Phan LT, Nemoto PA, Chu DT, Plattner JJ, Zhang X, Zhong P, Cao Z, Nilius AM, Shortridge VD, Flamm R, Mitten M, Meulbroek J, Ewing P, Alder J, Or YS. Ma Z, et al. Among authors: phan lt. J Med Chem. 2001 Nov 22;44(24):4137-56. doi: 10.1021/jm0102349. J Med Chem. 2001. PMID: 11708916

3

Synthesis of novel 6,11-O-bridged bicyclic ketolides via a palladium-catalyzed bis-allylation.

Wang G, Niu D, Qiu YL, Phan LT, Chen Z, Polemeropoulos A, Or YS. Wang G, et al. Among authors: phan lt. Org Lett. 2004 Nov 25;6(24):4455-8. doi: 10.1021/ol048336r. Org Lett. 2004. PMID: 15548049

4

Synthesis of new 14-membered macrolide antibiotics via a novel ring contraction metathesis.

Lazarova TI, Binet SM, Vo NH, Chen JS, Phan LT, Or YS. Lazarova TI, et al. Among authors: phan lt. Org Lett. 2003 Feb 20;5(4):443-5. doi: 10.1021/ol027322n. Org Lett. 2003. PMID: 12583739

5

Synthesis of novel 4'-substituted 16-membered ring macrolide antibiotics derived from leucomycins.

Wang Z, Jian T, Phan LT, Or YS. Wang Z, et al. Among authors: phan lt. Bioorg Med Chem Lett. 2004 Jan 19;14(2):519-21. doi: 10.1016/j.bmcl.2003.10.028. Bioorg Med Chem Lett. 2004. PMID: 14698194

6

Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolides derived from tylosin.

Phan LT, Jian T, Chen Z, Qiu YL, Wang Z, Beach T, Polemeropoulos A, Or YS. Phan LT, et al. J Med Chem. 2004 Jun 3;47(12):2965-8. doi: 10.1021/jm034233n. J Med Chem. 2004. PMID: 15163176

7

In vitro activities of the novel bicyclolides modithromycin (EDP-420, EP-013420, S-013420) and EDP-322 against MDR clinical Neisseria gonorrhoeae isolates and international reference strains.

Jacobsson S, Golparian D, Phan LT, Ohnishi M, Fredlund H, Or YS, Unemo M. Jacobsson S, et al. Among authors: phan lt. J Antimicrob Chemother. 2015 Jan;70(1):173-7. doi: 10.1093/jac/dku344. Epub 2014 Sep 1. J Antimicrob Chemother. 2015. PMID: 25182063

8

Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine.

Stork G, Yamashita A, Hanson RM, Phan L, Phillips E, Dubé D, Bos PH, Clark AJ, Gough M, Greenlee ML, Jiang Y, Jones K, Kitamura M, Leonard J, Liu T, Parsons PJ, Venkatesan AM. Stork G, et al. Org Lett. 2017 Oct 6;19(19):5150-5153. doi: 10.1021/acs.orglett.7b02434. Epub 2017 Sep 6. Org Lett. 2017. PMID: 28876074

9

Pharmacodynamic profiling of modithromycin: assessment in a pneumococcal murine pneumonia model.

Maglio D, Sun HK, Patel T, Banevicius MA, Nightingale CH, Arya A, Wang G, Chen Z, Phan LT, Nicolau DP. Maglio D, et al. Among authors: phan lt. Int J Antimicrob Agents. 2014 Jun;43(6):540-6. doi: 10.1016/j.ijantimicag.2014.01.029. Epub 2014 Mar 19. Int J Antimicrob Agents. 2014. PMID: 24703590

10

EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium.

Bermudez LE, Motamedi N, Chee C, Baimukanova G, Kolonoski P, Inderlied C, Aralar P, Wang G, Phan LT, Young LS. Bermudez LE, et al. Among authors: phan lt. Antimicrob Agents Chemother. 2007 May;51(5):1666-70. doi: 10.1128/AAC.01303-06. Epub 2007 Feb 12. Antimicrob Agents Chemother. 2007. PMID: 17296742 Free PMC article.

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