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(S)-4-Methyl-2-(methylamino)pentanoic acid [4, 4-bis(4-fluorophenyl)butyl]amide hydrochloride, a novel calcium channel antagonist, is efficacious in several animal models of pain.
Song Y, Bowersox SS, Connor DT, Dooley DJ, Lotarski SM, Malone T, Miljanich G, Millerman E, Rafferty MF, Rock D, Roth BD, Schmidt J, Stoehr S, Szoke BG, Taylor C, Vartanian M, Wang YX. Song Y, et al. Among authors: vartanian m. J Med Chem. 2000 Sep 21;43(19):3474-7. doi: 10.1021/jm000134n. J Med Chem. 2000. PMID: 11000000 No abstract available.
N,N-dialkyl-dipeptidylamines as novel N-type calcium channel blockers.
Hu LY, Ryder TR, Rafferty MF, Cody WL, Lotarski SM, Miljanich GP, Millerman E, Rock DM, Song Y, Stoehr SJ, Taylor CP, Weber ML, Szoke BG, Vartanian MG. Hu LY, et al. Among authors: vartanian mg. Bioorg Med Chem Lett. 1999 Mar 22;9(6):907-12. doi: 10.1016/s0960-894x(99)00100-6. Bioorg Med Chem Lett. 1999. PMID: 10206559
Carboxylate bioisosteres of gabapentin.
Burgos-Lepley CE, Thompson LR, Kneen CO, Osborne SA, Bryans JS, Capiris T, Suman-Chauhan N, Dooley DJ, Donovan CM, Field MJ, Vartanian MG, Kinsora JJ, Lotarski SM, El-Kattan A, Walters K, Cherukury M, Taylor CP, Wustrow DJ, Schwarz JB. Burgos-Lepley CE, et al. Among authors: vartanian mg. Bioorg Med Chem Lett. 2006 May 1;16(9):2333-6. doi: 10.1016/j.bmcl.2005.05.016. Epub 2005 Jun 8. Bioorg Med Chem Lett. 2006. PMID: 15946842
Carboxylate bioisosteres of pregabalin.
Schwarz JB, Colbry NL, Zhu Z, Nichelson B, Barta NS, Lin K, Hudack RA, Gibbons SE, Galatsis P, DeOrazio RJ, Manning DD, Vartanian MG, Kinsora JJ, Lotarski SM, Li Z, Dickerson MR, El-Kattan A, Thorpe AJ, Donevan SD, Taylor CP, Wustrow DJ. Schwarz JB, et al. Among authors: vartanian mg. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3559-63. doi: 10.1016/j.bmcl.2006.03.083. Epub 2006 Apr 18. Bioorg Med Chem Lett. 2006. PMID: 16621528
Oxadiazolone bioisosteres of pregabalin and gabapentin.
Wustrow DJ, Belliotti TR, Capiris T, Kneen CO, Bryans JS, Field MJ, Williams D, El-Kattan A, Buchholz L, Kinsora JJ, Lotarski SM, Vartanian MG, Taylor CP, Donevan SD, Thorpe AJ, Schwarz JB. Wustrow DJ, et al. Among authors: vartanian mg. Bioorg Med Chem Lett. 2009 Jan 1;19(1):247-50. doi: 10.1016/j.bmcl.2008.10.101. Epub 2008 Oct 25. Bioorg Med Chem Lett. 2009. PMID: 19010672
Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity.
Bigge CF, Malone TC, Boxer PA, Nelson CB, Ortwine DF, Schelkun RM, Retz DM, Lescosky LJ, Borosky SA, Vartanian MG, et al. Bigge CF, et al. Among authors: vartanian mg. J Med Chem. 1995 Sep 15;38(19):3720-40. doi: 10.1021/jm00019a003. J Med Chem. 1995. PMID: 7562904
101 results