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Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner.
Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, Saffitz JE, Medeiros DM, Valencik ML, McDonald JA, Kelly DP. Russell LK, et al. Among authors: medeiros dm. Circ Res. 2004 Mar 5;94(4):525-33. doi: 10.1161/01.RES.0000117088.36577.EB. Epub 2004 Jan 15. Circ Res. 2004. PMID: 14726475
PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.
Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP. Leone TC, et al. Among authors: medeiros dm. PLoS Biol. 2005 Apr;3(4):e101. doi: 10.1371/journal.pbio.0030101. Epub 2005 Mar 15. PLoS Biol. 2005. PMID: 15760270 Free PMC article.
Assessing mitochondria biogenesis.
Medeiros DM. Medeiros DM. Methods. 2008 Dec;46(4):288-94. doi: 10.1016/j.ymeth.2008.09.026. Epub 2008 Oct 16. Methods. 2008. PMID: 18929661 Free article. Review.
Differential expression of genes involved with apoptosis, cell cycle, connective tissue proteins, fuel substrate utilization, inflammation and mitochondrial biogenesis in copper-deficient rat hearts: implication of a role for Nfkappab1.
Klaahsen D, Ricklefs K, Medeiros DM. Klaahsen D, et al. Among authors: medeiros dm. J Nutr Biochem. 2007 Nov;18(11):719-26. doi: 10.1016/j.jnutbio.2006.11.011. Epub 2007 Apr 5. J Nutr Biochem. 2007. PMID: 17418555 Free article.
155 results