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In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the release of beta interferon.
Mangino G, Percario ZA, Fiorucci G, Vaccari G, Manrique S, Romeo G, Federico M, Geyer M, Affabris E. Mangino G, et al. J Virol. 2007 Mar;81(6):2777-91. doi: 10.1128/JVI.01640-06. Epub 2006 Dec 20. J Virol. 2007. PMID: 17182689 Free PMC article.
Human immunodeficiency virus type 1 (HIV-1) Nef activates STAT3 in primary human monocyte/macrophages through the release of soluble factors: involvement of Nef domains interacting with the cell endocytotic machinery.
Percario Z, Olivetta E, Fiorucci G, Mangino G, Peretti S, Romeo G, Affabris E, Federico M. Percario Z, et al. Among authors: mangino g. J Leukoc Biol. 2003 Nov;74(5):821-32. doi: 10.1189/jlb.0403161. Epub 2003 Jul 22. J Leukoc Biol. 2003. PMID: 12960275
76 results