Brown R - Search Results

1

Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter.

Plumb JA, Strathdee G, Sludden J, Kaye SB, Brown R. Plumb JA, et al. Among authors: brown r. Cancer Res. 2000 Nov 1;60(21):6039-44. Cancer Res. 2000. PMID: 11085525

2

The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients.

Gifford G, Paul J, Vasey PA, Kaye SB, Brown R. Gifford G, et al. Among authors: brown r. Clin Cancer Res. 2004 Jul 1;10(13):4420-6. doi: 10.1158/1078-0432.CCR-03-0732. Clin Cancer Res. 2004. PMID: 15240532 Clinical Trial.

3

Demethylation of DNA by decitabine in cancer chemotherapy.

Brown R, Plumb JA. Brown R, et al. Expert Rev Anticancer Ther. 2004 Aug;4(4):501-10. doi: 10.1586/14737140.4.4.501. Expert Rev Anticancer Ther. 2004. PMID: 15270655 Review.

4

Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101.

Plumb JA, Finn PW, Williams RJ, Bandara MJ, Romero MR, Watkins CJ, La Thangue NB, Brown R. Plumb JA, et al. Among authors: brown r. Mol Cancer Ther. 2003 Aug;2(8):721-8. Mol Cancer Ther. 2003. PMID: 12939461

5

A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer.

Strathdee G, MacKean MJ, Illand M, Brown R. Strathdee G, et al. Among authors: brown r. Oncogene. 1999 Apr 8;18(14):2335-41. doi: 10.1038/sj.onc.1202540. Oncogene. 1999. PMID: 10327053

6

Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo.

Steele N, Finn P, Brown R, Plumb JA. Steele N, et al. Among authors: brown r. Br J Cancer. 2009 Mar 10;100(5):758-63. doi: 10.1038/sj.bjc.6604932. Br J Cancer. 2009. PMID: 19259094 Free PMC article.

7

Epigenomics and epigenetic therapy of cancer.

Brown R, Strathdee G. Brown R, et al. Trends Mol Med. 2002;8(4 Suppl):S43-8. doi: 10.1016/s1471-4914(02)02314-6. Trends Mol Med. 2002. PMID: 11927287 Review.

8

Epigenetic cancer therapies: DNA methyltransferase inhibitors.

Strathdee G, Brown R. Strathdee G, et al. Among authors: brown r. Expert Opin Investig Drugs. 2002 Jun;11(6):747-54. doi: 10.1517/13543784.11.6.747. Expert Opin Investig Drugs. 2002. PMID: 12036419 Review.

9

Bioscience 2004.

Strathdee G, Brown R. Strathdee G, et al. Among authors: brown r. Pharmacogenomics. 2004 Oct;5(7):775-8. doi: 10.1517/14622416.5.7.775. Pharmacogenomics. 2004. PMID: 15469402 No abstract available.

10

Epigenetic silencing mediated by CpG island methylation: potential as a therapeutic target and as a biomarker.

Teodoridis JM, Strathdee G, Brown R. Teodoridis JM, et al. Among authors: brown r. Drug Resist Updat. 2004 Aug-Oct;7(4-5):267-78. doi: 10.1016/j.drup.2004.06.005. Drug Resist Updat. 2004. PMID: 15533764 Review.

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