Leblond L - Search Results

1

In vitro and in vivo properties of bicyclic lactam inhibitors: a novel class of low molecular weight peptidomimetic thrombin inhibitors.

Leblond L, Grouix B, Boudreau C, Yang Q, Siddiqui MA, Winocour PD. Leblond L, et al. Thromb Res. 2000 Nov 1;100(3):195-209. doi: 10.1016/s0049-3848(00)00333-9. Thromb Res. 2000. PMID: 11108907

2

Novel bicyclic lactam inhibitors of thrombin: highly potent and selective inhibitors.

St-Denis Y, Lévesque S, Bachand B, Edmunds JJ, Leblond L, Préville P, Tarazi M, Winocour PD, Siddiqui MA. St-Denis Y, et al. Among authors: leblond l. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1181-4. doi: 10.1016/s0960-894x(02)00131-2. Bioorg Med Chem Lett. 2002. PMID: 11934583

3

BCH-2763, a novel potent parenteral thrombin inhibitor, is an effective antithrombotic agent in rodent models of arterial and venous thrombosis--comparisons with heparin, r-hirudin, hirulog, inogatran and argatroban.

Finkle CD, St Pierre A, Leblond L, Deschenes I, DiMaio J, Winocour PD. Finkle CD, et al. Among authors: leblond l. Thromb Haemost. 1998 Feb;79(2):431-8. Thromb Haemost. 1998. PMID: 9493603

4

Potent bicyclic lactam inhibitors of thrombin: Part I: P3 modifications.

St-Denis Y, Augelli-Szafran CE, Bachand B, Berryman KA, DiMaio J, Doherty AM, Edmunds JJ, Leblond L, Lévesque S, Narasimhan LS, Penvose-Yi JR, Rubin JR, Tarazi M, Winocour PD, Siddiqui MA. St-Denis Y, et al. Among authors: leblond l. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3193-8. doi: 10.1016/s0960-894x(98)00550-2. Bioorg Med Chem Lett. 1998. PMID: 9873701

5

Insertion of the Asp-Ser/Phe sequence in the P' position of hirutonin provides molecules having both antithrombin and disintegrin activity.

Leblond L, DiMaio J, Winocour PD. Leblond L, et al. Thromb Res. 1999 Feb 15;93(4):171-81. doi: 10.1016/s0049-3848(98)00182-0. Thromb Res. 1999. PMID: 10064272

6

Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: transition state inhibitors.

Bachand B, Tarazi M, St-Denis Y, Edmunds JJ, Winocour PD, Leblond L, Siddiqui MA. Bachand B, et al. Among authors: leblond l. Bioorg Med Chem Lett. 2001 Feb 12;11(3):287-90. doi: 10.1016/s0960-894x(00)00636-3. Bioorg Med Chem Lett. 2001. PMID: 11212093

7

Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues.

Lévesque S, St-Denis Y, Bachand B, Préville P, Leblond L, Winocour PD, Edmunds JJ, Rubin JR, Siddiqui MA. Lévesque S, et al. Among authors: leblond l. Bioorg Med Chem Lett. 2001 Dec 17;11(24):3161-4. doi: 10.1016/s0960-894x(01)00661-8. Bioorg Med Chem Lett. 2001. PMID: 11720865

8

Incorporation of an Asp-Ser sequence to form an RGDS-like motif in hirutonin: the effect on in vitro platelet function.

van Wyk V, Leblond L, Winocour PD, Devine DV, Gyongyossy-Issa MI. van Wyk V, et al. Among authors: leblond l. Thromb Res. 2000 Aug 15;99(4):343-52. doi: 10.1016/s0049-3848(00)00257-7. Thromb Res. 2000. PMID: 10963785

9

The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: part 2.

Cody WL, Augelli-Szafran CE, Berryman KA, Cai C, Doherty AM, Edmunds JJ, He JX, Narasimhan LS, Penvose-Yi J, Plummer JS, Rapundalo ST, Rubin JR, Van Huis CA, Leblond L, Winocour PD, Siddiqui MA. Cody WL, et al. Among authors: leblond l. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2503-8. doi: 10.1016/s0960-894x(99)00419-9. Bioorg Med Chem Lett. 1999. PMID: 10498197

10

Species differences in troxacitabine pharmacokinetics and pharmacodynamics: implications for clinical development.

Gourdeau H, Leblond L, Hamelin B, Dong K, Ouellet F, Boudreau C, Custeau D, Richard A, Gilbert MJ, Jolivet J. Gourdeau H, et al. Among authors: leblond l. Clin Cancer Res. 2004 Nov 15;10(22):7692-702. doi: 10.1158/1078-0432.CCR-04-0657. Clin Cancer Res. 2004. PMID: 15570003

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