Copeland WC - Search Results

1

Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine.

Furman PA, Jeffrey J, Kiefer LL, Feng JY, Anderson KS, Borroto-Esoda K, Hill E, Copeland WC, Chu CK, Sommadossi JP, Liberman I, Schinazi RF, Painter GR. Furman PA, et al. Among authors: copeland wc. Antimicrob Agents Chemother. 2001 Jan;45(1):158-65. doi: 10.1128/AAC.45.1.158-165.2001. Antimicrob Agents Chemother. 2001. PMID: 11120959 Free PMC article.

2

R964C mutation of DNA polymerase gamma imparts increased stavudine toxicity by decreasing nucleoside analog discrimination and impairing polymerase activity.

Bailey CM, Kasiviswanathan R, Copeland WC, Anderson KS. Bailey CM, et al. Among authors: copeland wc. Antimicrob Agents Chemother. 2009 Jun;53(6):2610-2. doi: 10.1128/AAC.01659-08. Epub 2009 Apr 13. Antimicrob Agents Chemother. 2009. PMID: 19364868 Free PMC article.

3

Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity.

Sohl CD, Singh K, Kasiviswanathan R, Copeland WC, Mitsuya H, Sarafianos SG, Anderson KS. Sohl CD, et al. Among authors: copeland wc. Antimicrob Agents Chemother. 2012 Mar;56(3):1630-4. doi: 10.1128/AAC.05729-11. Epub 2011 Dec 12. Antimicrob Agents Chemother. 2012. PMID: 22155823 Free PMC article.

4

Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.

Sohl CD, Kasiviswanathan R, Kim J, Pradere U, Schinazi RF, Copeland WC, Mitsuya H, Baba M, Anderson KS. Sohl CD, et al. Among authors: copeland wc. Mol Pharmacol. 2012 Jul;82(1):125-33. doi: 10.1124/mol.112.078758. Epub 2012 Apr 18. Mol Pharmacol. 2012. PMID: 22513406 Free PMC article.

5

Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients.

Sohl CD, Kasiviswanathan R, Copeland WC, Anderson KS. Sohl CD, et al. Among authors: copeland wc. Hum Mol Genet. 2013 Mar 15;22(6):1074-85. doi: 10.1093/hmg/dds509. Epub 2012 Dec 3. Hum Mol Genet. 2013. PMID: 23208208 Free PMC article.

6

Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma.

Lim SE, Copeland WC. Lim SE, et al. Among authors: copeland wc. J Biol Chem. 2001 Jun 29;276(26):23616-23. doi: 10.1074/jbc.M101114200. Epub 2001 Apr 23. J Biol Chem. 2001. PMID: 11319228 Free article.

7

Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs.

Lim SE, Ponamarev MV, Longley MJ, Copeland WC. Lim SE, et al. Among authors: copeland wc. J Mol Biol. 2003 May 23;329(1):45-57. doi: 10.1016/s0022-2836(03)00405-4. J Mol Biol. 2003. PMID: 12742017

8

Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.

Chan SS, Santos JH, Meyer JN, Mandavilli BS, Cook DL Jr, McCash CL, Kissling GE, Nyska A, Foley JF, van Houten B, Copeland WC, Walker VE, Witt KL, Bishop JB. Chan SS, et al. Among authors: copeland wc. Environ Mol Mutagen. 2007 Apr-May;48(3-4):190-200. doi: 10.1002/em.20191. Environ Mol Mutagen. 2007. PMID: 16395692

9

mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae.

Stumpf JD, Bailey CM, Spell D, Stillwagon M, Anderson KS, Copeland WC. Stumpf JD, et al. Among authors: copeland wc. Hum Mol Genet. 2010 Jun 1;19(11):2123-33. doi: 10.1093/hmg/ddq089. Epub 2010 Feb 25. Hum Mol Genet. 2010. PMID: 20185557 Free PMC article.

10

Selective action of 4'-azidothymidine triphosphate on reverse transcriptase of human immunodeficiency virus type 1 and human DNA polymerases alpha and beta.

Chen MS, Suttmann RT, Papp E, Cannon PD, McRoberts MJ, Bach C, Copeland WC, Wang TS. Chen MS, et al. Among authors: copeland wc. Biochemistry. 1993 Jun 15;32(23):6002-10. doi: 10.1021/bi00074a011. Biochemistry. 1993. PMID: 7685186

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