The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts.
Burgess TL, Qian Y, Kaufman S, Ring BD, Van G, Capparelli C, Kelley M, Hsu H, Boyle WJ, Dunstan CR, Hu S, Lacey DL.
Burgess TL, et al. Among authors: dunstan cr.
J Cell Biol. 1999 May 3;145(3):527-38. doi: 10.1083/jcb.145.3.527.
J Cell Biol. 1999.
PMID: 10225954
Free PMC article.
Osteoprotegerin (OPG) and OPG-ligand (OPGL) potently inhibit and stimulate, respectively, osteoclast differentiation (Simonet, W.S., D.L. Lacey, C.R. Dunstan, M. Kelley, M.-S. Chang, R. Luethy, H.Q. Nguyen, S. Wooden, L. Bennett, T. ...Cell. 89:309-319; Lacey, D.L., …
Osteoprotegerin (OPG) and OPG-ligand (OPGL) potently inhibit and stimulate, respectively, osteoclast differentiation (Simonet, W.S., D.L. La …