Doyle TW - Search Results

1

Syntheses and antitumor activities of potent inhibitors of ribonucleotide reductase: 3-amino-4-methylpyridine-2-carboxaldehyde-thiosemicarba-zone (3-AMP), 3-amino-pyridine-2-carboxaldehyde-thiosemicarbazone (3-AP) and its water-soluble prodrugs.

Li J, Zheng LM, King I, Doyle TW, Chen SH. Li J, et al. Among authors: doyle tw. Curr Med Chem. 2001 Feb;8(2):121-33. doi: 10.2174/0929867013373741. Curr Med Chem. 2001. PMID: 11172670 Review.

2

Synthesis and biological evaluation of a water soluble phosphate prodrug of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP).

Li J, Luo X, Wang Q, Zheng LM, King I, Doyle TW, Chen SH. Li J, et al. Among authors: doyle tw. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3159-64. doi: 10.1016/s0960-894x(98)00573-3. Bioorg Med Chem Lett. 1998. PMID: 9873695

3

Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd4C and beta-D-Fd4C.

Chen SH, Lin S, King I, Spinka T, Dutschman GE, Gullen EA, Cheng YC, Doyle TW. Chen SH, et al. Among authors: doyle tw. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3245-50. doi: 10.1016/s0960-894x(98)00599-x. Bioorg Med Chem Lett. 1998. PMID: 9873711 Free article.

4

Bis-S-acyl-2-thioethyl (SATE)-bearing monophosphate prodrug of beta-L-FD4C as potent anti-HBV agent.

Li X, Carmichael E, Feng M, King I, Doyle TW, Chen SH. Li X, et al. Among authors: doyle tw. Bioorg Med Chem Lett. 1998 Jan 6;8(1):57-62. doi: 10.1016/s0960-894x(97)10178-0. Bioorg Med Chem Lett. 1998. PMID: 9871628

5

Synthesis and biological evaluation of a series of 2'-fluorinated-2',3'-dideoxy-2',3'-didehydro-(L)-nucleosides.

Chen SH, Wang Q, Mao J, King I, Dutschman GE, Gullen EA, Cheng YC, Doyle TW. Chen SH, et al. Among authors: doyle tw. Bioorg Med Chem Lett. 1998 Jul 7;8(13):1589-94. doi: 10.1016/s0960-894x(98)00277-7. Bioorg Med Chem Lett. 1998. PMID: 9873396 Free article. No abstract available.

6

Synthesis of a paclitaxel isomer: C-2-acetoxy-C-4-benzoate paclitaxel.

Chen SH, Farina V, Vyas DM, Doyle TW. Chen SH, et al. Among authors: doyle tw. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2227-30. doi: 10.1016/s0960-894x(98)00383-7. Bioorg Med Chem Lett. 1998. PMID: 9873518

7

Structural modifications of anguidin and antitumor activities of its analogues.

Kaneko T, Schmitz H, Essery JM, Rose W, Howell HG, O'Herron FA, Nachfolger S, Huftalen J, Bradner WT, Partyka RA, Doyle TW, Davies J, Cundliffe E. Kaneko T, et al. Among authors: doyle tw. J Med Chem. 1982 May;25(5):579-89. doi: 10.1021/jm00347a018. J Med Chem. 1982. PMID: 7086845

8

Reductive amination of 3-ketoanguidin and antitumor activity of the products.

Kaneko T, Wong H, Howell HG, Rose WC, Bradner WT, Doyle TW. Kaneko T, et al. Among authors: doyle tw. J Med Chem. 1985 Jul;28(7):958-60. doi: 10.1021/jm00145a019. J Med Chem. 1985. PMID: 4009618

9

Isolation and identification of metabolites of porfiromycin formed in the presence of a rat liver preparation.

Lang W, Mao J, Wang Q, Niu C, Doyle TW, Almassian B. Lang W, et al. Among authors: doyle tw. J Pharm Sci. 2000 Feb;89(2):191-8. doi: 10.1002/(SICI)1520-6017(200002)89:2<191::AID-JPS6>3.0.CO;2-1. J Pharm Sci. 2000. PMID: 10688748

10

Synthesis and in vivo antitumor activity of novel mitomycin A disulfide analogs.

Vyas DM, Benigni D, Rose WC, Bradner WT, Doyle TW. Vyas DM, et al. Among authors: doyle tw. J Antibiot (Tokyo). 1989 Jul;42(7):1199-201. doi: 10.7164/antibiotics.42.1199. J Antibiot (Tokyo). 1989. PMID: 2753826 Free article. No abstract available.

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