Wang R - Search Results

1

An empirical model of gamma-secretase activity.

Murphy MP, Wang R, Fraser PE, Fauq A, Golde TE. Murphy MP, et al. Among authors: wang r. Ann N Y Acad Sci. 2000;920:233-40. doi: 10.1111/j.1749-6632.2000.tb06928.x. Ann N Y Acad Sci. 2000. PMID: 11193156

2

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length.

Murphy MP, Hickman LJ, Eckman CB, Uljon SN, Wang R, Golde TE. Murphy MP, et al. Among authors: wang r. J Biol Chem. 1999 Apr 23;274(17):11914-23. doi: 10.1074/jbc.274.17.11914. J Biol Chem. 1999. PMID: 10207012 Free article.

3

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage.

Murphy MP, Uljon SN, Fraser PE, Fauq A, Lookingbill HA, Findlay KA, Smith TE, Lewis PA, McLendon DC, Wang R, Golde TE. Murphy MP, et al. Among authors: wang r. J Biol Chem. 2000 Aug 25;275(34):26277-84. doi: 10.1074/jbc.M002812200. J Biol Chem. 2000. PMID: 10816583 Free article.

4

Cell-free assays for gamma-secretase activity.

McLendon C, Xin T, Ziani-Cherif C, Murphy MP, Findlay KA, Lewis PA, Pinnix I, Sambamurti K, Wang R, Fauq A, Golde TE. McLendon C, et al. Among authors: wang r. FASEB J. 2000 Dec;14(15):2383-6. doi: 10.1096/fj.00-0286fje. FASEB J. 2000. PMID: 11024004

5

Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides.

Lewis PA, Piper S, Baker M, Onstead L, Murphy MP, Hardy J, Wang R, McGowan E, Golde TE. Lewis PA, et al. Among authors: wang r. Biochim Biophys Acta. 2001 Jul 27;1537(1):58-62. doi: 10.1016/s0925-4439(01)00054-0. Biochim Biophys Acta. 2001. PMID: 11476963 Free article.

6

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.

Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. Weggen S, et al. Among authors: wang r. Nature. 2001 Nov 8;414(6860):212-6. doi: 10.1038/35102591. Nature. 2001. PMID: 11700559

7

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.

Yu C, Kim SH, Ikeuchi T, Xu H, Gasparini L, Wang R, Sisodia SS. Yu C, et al. Among authors: wang r. J Biol Chem. 2001 Nov 23;276(47):43756-60. doi: 10.1074/jbc.C100410200. Epub 2001 Oct 2. J Biol Chem. 2001. PMID: 11583985 Free article.

8

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein.

Lichtenthaler SF, Wang R, Grimm H, Uljon SN, Masters CL, Beyreuther K. Lichtenthaler SF, et al. Among authors: wang r. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3053-8. doi: 10.1073/pnas.96.6.3053. Proc Natl Acad Sci U S A. 1999. PMID: 10077635 Free PMC article.

9

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.

Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Fraser P, Westaway D, St George-Hyslop PH, Szabo P, Relkin NR, Buxbaum JD, Glabe CG, Protter AA, Martins RN, Ehrlich ME, Petsko GA, Yue Z, Gandy S. Steele JW, et al. Among authors: wang r. Mol Psychiatry. 2013 Aug;18(8):889-97. doi: 10.1038/mp.2012.106. Epub 2012 Jul 31. Mol Psychiatry. 2013. PMID: 22850627 Free PMC article.

10

Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes.

McGowan E, Sanders S, Iwatsubo T, Takeuchi A, Saido T, Zehr C, Yu X, Uljon S, Wang R, Mann D, Dickson D, Duff K. McGowan E, et al. Among authors: wang r. Neurobiol Dis. 1999 Aug;6(4):231-44. doi: 10.1006/nbdi.1999.0243. Neurobiol Dis. 1999. PMID: 10448051

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