Pagnozzi MJ - Search Results

1

Atropisomeric quinazolin-4-one derivatives are potent noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists.

Welch WM, Ewing FE, Huang J, Menniti FS, Pagnozzi MJ, Kelly K, Seymour PA, Guanowsky V, Guhan S, Guinn MR, Critchett D, Lazzaro J, Ganong AH, DeVries KM, Staigers TL, Chenard BL. Welch WM, et al. Among authors: pagnozzi mj. Bioorg Med Chem Lett. 2001 Jan 22;11(2):177-81. doi: 10.1016/s0960-894x(00)00622-3. Bioorg Med Chem Lett. 2001. PMID: 11206453

2

(3R,4S)-3-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]chroman-4,7-diol: a conformationally restricted analogue of the NR2B subtype-selective NMDA antagonist (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)- 1-propanol.

Butler TW, Blake JF, Bordner J, Butler P, Chenard BL, Collins MA, DeCosta D, Ducat MJ, Eisenhard ME, Menniti FS, Pagnozzi MJ, Sands SB, Segelstein BE, Volberg W, White WF, Zhao D. Butler TW, et al. Among authors: pagnozzi mj. J Med Chem. 1998 Mar 26;41(7):1172-84. doi: 10.1021/jm9707986. J Med Chem. 1998. PMID: 9544217

3

Methaqualone derivatives are potent noncompetitive AMPA receptor antagonists.

Chenard BL, Menniti FS, Pagnozzi MJ, Shenk KD, Ewing FE, Welch WM. Chenard BL, et al. Among authors: pagnozzi mj. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1203-5. doi: 10.1016/s0960-894x(00)00216-x. Bioorg Med Chem Lett. 2000. PMID: 10866381

4

Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists.

Menniti FS, Chenard BL, Collins MB, Ducat MF, Elliott ML, Ewing FE, Huang JI, Kelly KA, Lazzaro JT, Pagnozzi MJ, Weeks JL, Welch WM, White WF. Menniti FS, et al. Among authors: pagnozzi mj. Mol Pharmacol. 2000 Dec;58(6):1310-7. doi: 10.1124/mol.58.6.1310. Mol Pharmacol. 2000. PMID: 11093768

5

Quinazolin-4-one alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists: structure-activity relationship of the C-2 side chain tether.

Chenard BL, Welch WM, Blake JF, Butler TW, Reinhold A, Ewing FE, Menniti FS, Pagnozzi MJ. Chenard BL, et al. Among authors: pagnozzi mj. J Med Chem. 2001 May 24;44(11):1710-7. doi: 10.1021/jm000522p. J Med Chem. 2001. PMID: 11356106

6

CP-101,606, an NR2B subunit selective NMDA receptor antagonist, inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents.

Menniti FS, Pagnozzi MJ, Butler P, Chenard BL, Jaw-Tsai SS, Frost White W. Menniti FS, et al. Among authors: pagnozzi mj. Neuropharmacology. 2000 Apr 27;39(7):1147-55. doi: 10.1016/s0028-3908(99)00211-7. Neuropharmacology. 2000. PMID: 10760358

7

A unified approach to systematic isosteric substitution for acidic groups and application to NMDA antagonists related to 2-amino-7-phosphonoheptanoate.

Chenard BL, Lipinski CA, Dominy BW, Mena EE, Ronau RT, Butterfield GC, Marinovic LC, Pagnozzi M, Butler TW, Tsang T. Chenard BL, et al. J Med Chem. 1990 Mar;33(3):1077-83. doi: 10.1021/jm00165a030. J Med Chem. 1990. PMID: 2155321

8

Conantokin-G: a novel peptide antagonist to the N-methyl-D-aspartic acid (NMDA) receptor.

Mena EE, Gullak MF, Pagnozzi MJ, Richter KE, Rivier J, Cruz LJ, Olivera BM. Mena EE, et al. Among authors: pagnozzi mj. Neurosci Lett. 1990 Oct 16;118(2):241-4. doi: 10.1016/0304-3940(90)90637-o. Neurosci Lett. 1990. PMID: 2177176

9

Characterization of L-glutamate binding sites in rat spinal cord synaptic membranes: evidence for multiple chloride ion-dependent sites.

Mena EE, Pagnozzi MJ, Gullak MF. Mena EE, et al. Among authors: pagnozzi mj. J Neurochem. 1986 Oct;47(4):1052-60. doi: 10.1111/j.1471-4159.1986.tb00719.x. J Neurochem. 1986. PMID: 2875127

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