Saavedra JE - Search Results

1

V-PYRRO/NO: an hepato-selective nitric oxide donor improves porcine liver hemodynamics and function after ischemia reperfusion.

Ricciardi R, Foley DP, Quarfordt SH, Saavedra JE, Keefer LK, Wheeler SM, Donohue SE, Callery MP, Meyers WC. Ricciardi R, et al. Among authors: saavedra je. Transplantation. 2001 Jan 27;71(2):193-8. doi: 10.1097/00007890-200101270-00004. Transplantation. 2001. PMID: 11213058

2

The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice.

Liu J, Li C, Waalkes MP, Clark J, Myers P, Saavedra JE, Keefer LK. Liu J, et al. Among authors: saavedra je. Hepatology. 2003 Feb;37(2):324-33. doi: 10.1053/jhep.2003.50063. Hepatology. 2003. PMID: 12540782

3

Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver.

Saavedra JE, Billiar TR, Williams DL, Kim YM, Watkins SC, Keefer LK. Saavedra JE, et al. J Med Chem. 1997 Jun 20;40(13):1947-54. doi: 10.1021/jm9701031. J Med Chem. 1997. PMID: 9207935

4

O(2)-Vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate protection against D-galactosamine/endotoxin-induced hepatotoxicity in mice: genomic analysis using microarrays.

Liu J, Saavedra JE, Lu T, Song JG, Clark J, Waalkes MP, Keefer LK. Liu J, et al. Among authors: saavedra je. J Pharmacol Exp Ther. 2002 Jan;300(1):18-25. doi: 10.1124/jpet.300.1.18. J Pharmacol Exp Ther. 2002. PMID: 11752092

5

The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced nephrotoxicity in mice.

Li C, Liu J, Saavedra JE, Keefer LK, Waalkes MP. Li C, et al. Among authors: saavedra je. Toxicology. 2003 Aug 1;189(3):173-80. doi: 10.1016/s0300-483x(03)00129-x. Toxicology. 2003. PMID: 12832150

6

The nitric oxide prodrug, V-PYRRO/NO, protects against cadmium toxicity and apoptosis at the cellular level.

Qu W, Liu J, Fuquay R, Shimoda R, Sakurai T, Saavedra JE, Keefer LK, Waalkes MP. Qu W, et al. Among authors: saavedra je. Nitric Oxide. 2005 Mar;12(2):114-20. doi: 10.1016/j.niox.2005.01.005. Nitric Oxide. 2005. PMID: 15740985

7

Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia.

Ou J, Carlos TM, Watkins SC, Saavedra JE, Keefer LK, Kim YM, Harbrecht BG, Billiar TR. Ou J, et al. Among authors: saavedra je. Nitric Oxide. 1997 Oct;1(5):404-16. doi: 10.1006/niox.1997.0136. Nitric Oxide. 1997. PMID: 9441911

8

Plasma pharmacokinetics of a liver-selective nitric oxide-donating diazeniumdiolate in the male C57BL/6 mouse.

Stinson SF, House T, Bramhall C, Saavedra JE, Keefer LK, Nims RW. Stinson SF, et al. Among authors: saavedra je. Xenobiotica. 2002 Apr;32(4):339-47. doi: 10.1080/00498250110102665. Xenobiotica. 2002. PMID: 12028666

9

Metabolism of a liver-selective nitric oxide-releasing agent, V-PYRRO/NO, by human microsomal cytochromes P450.

Inami K, Nims RW, Srinivasan A, Citro ML, Saavedra JE, Cederbaum AI, Keefer LK. Inami K, et al. Among authors: saavedra je. Nitric Oxide. 2006 Jun;14(4):309-15. doi: 10.1016/j.niox.2006.01.003. Epub 2006 Mar 20. Nitric Oxide. 2006. PMID: 16545970

10

The nitric oxide prodrug, V-PYRRO/NO, mitigates arsenic-induced liver cell toxicity and apoptosis.

Qu W, Liu J, Fuquay R, Saavedra JE, Keefer LK, Waalkes MP. Qu W, et al. Among authors: saavedra je. Cancer Lett. 2007 Oct 28;256(2):238-45. doi: 10.1016/j.canlet.2007.06.009. Epub 2007 Jul 20. Cancer Lett. 2007. PMID: 17658681 Free PMC article.

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