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Page 1
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, Ellis C, Elshourbagy NA, Goetz AS, Minnick DT, Murdock PR, Sauls HR Jr, Shabon U, Spinage LD, Strum JC, Szekeres PG, Tan KB, Way JM, Ignar DM, Wilson S, Muir AI. Briscoe CP, et al. J Biol Chem. 2003 Mar 28;278(13):11303-11. doi: 10.1074/jbc.M211495200. Epub 2002 Dec 19. J Biol Chem. 2003. PMID: 12496284 Free article.
A family of fatty acid binding receptors.
Brown AJ, Jupe S, Briscoe CP. Brown AJ, et al. Among authors: briscoe cp. DNA Cell Biol. 2005 Jan;24(1):54-61. doi: 10.1089/dna.2005.24.54. DNA Cell Biol. 2005. PMID: 15684720 Review.
Pharmacological characterization of a small molecule inhibitor of c-Jun kinase.
Cho H, Black SC, Looper D, Shi M, Kelly-Sullivan D, Timofeevski S, Siegel K, Yu XH, McDonnell SR, Chen P, Yie J, Ogilvie KM, Fraser J, Briscoe CP. Cho H, et al. Among authors: briscoe cp. Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1142-51. doi: 10.1152/ajpendo.90298.2008. Epub 2008 Aug 26. Am J Physiol Endocrinol Metab. 2008. PMID: 18728225 Free article.
Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.
Briscoe CP, Peat AJ, McKeown SC, Corbett DF, Goetz AS, Littleton TR, McCoy DC, Kenakin TP, Andrews JL, Ammala C, Fornwald JA, Ignar DM, Jenkinson S. Briscoe CP, et al. Br J Pharmacol. 2006 Jul;148(5):619-28. doi: 10.1038/sj.bjp.0706770. Epub 2006 May 15. Br J Pharmacol. 2006. PMID: 16702987 Free PMC article.
Synthesis and activity of small molecule GPR40 agonists.
Garrido DM, Corbett DF, Dwornik KA, Goetz AS, Littleton TR, McKeown SC, Mills WY, Smalley TL Jr, Briscoe CP, Peat AJ. Garrido DM, et al. Among authors: briscoe cp. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1840-5. doi: 10.1016/j.bmcl.2006.01.007. Epub 2006 Jan 24. Bioorg Med Chem Lett. 2006. PMID: 16439116
30 results