Krasowski MD - Search Results

1

General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility.

Krasowski MD, Jenkins A, Flood P, Kung AY, Hopfinger AJ, Harrison NL. Krasowski MD, et al. J Pharmacol Exp Ther. 2001 Apr;297(1):338-51. J Pharmacol Exp Ther. 2001. PMID: 11259561

2

4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor.

Krasowski MD, Hong X, Hopfinger AJ, Harrison NL. Krasowski MD, et al. J Med Chem. 2002 Jul 18;45(15):3210-21. doi: 10.1021/jm010461a. J Med Chem. 2002. PMID: 12109905 Free PMC article.

3

Alpha subunit isoform influences GABA(A) receptor modulation by propofol.

Krasowski MD, O'Shea SM, Rick CE, Whiting PJ, Hadingham KL, Czajkowski C, Harrison NL. Krasowski MD, et al. Neuropharmacology. 1997 Jul;36(7):941-9. doi: 10.1016/s0028-3908(97)00074-9. Neuropharmacology. 1997. PMID: 9257938 Free PMC article.

4

Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane.

Krasowski MD, Koltchine VV, Rick CE, Ye Q, Finn SE, Harrison NL. Krasowski MD, et al. Mol Pharmacol. 1998 Mar;53(3):530-8. doi: 10.1124/mol.53.3.530. Mol Pharmacol. 1998. PMID: 9495821

5

Trichloroethanol modulation of recombinant GABAA, glycine and GABA rho 1 receptors.

Krasowski MD, Finn SE, Ye Q, Harrison NL. Krasowski MD, et al. J Pharmacol Exp Ther. 1998 Mar;284(3):934-42. J Pharmacol Exp Ther. 1998. PMID: 9495852

6

The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations.

Krasowski MD, Harrison NL. Krasowski MD, et al. Br J Pharmacol. 2000 Feb;129(4):731-43. doi: 10.1038/sj.bjp.0703087. Br J Pharmacol. 2000. PMID: 10683198 Free PMC article.

7

Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics.

Krasowski MD, Nishikawa K, Nikolaeva N, Lin A, Harrison NL. Krasowski MD, et al. Neuropharmacology. 2001 Dec;41(8):952-64. doi: 10.1016/s0028-3908(01)00141-1. Neuropharmacology. 2001. PMID: 11747900 Free PMC article.

8

General anaesthetic actions on ligand-gated ion channels.

Krasowski MD, Harrison NL. Krasowski MD, et al. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. doi: 10.1007/s000180050371. Cell Mol Life Sci. 1999. PMID: 10487207 Free PMC article. Review.

9

Anesthetic properties of 4-iodopropofol: implications for mechanisms of anesthesia.

Lingamaneni R, Krasowski MD, Jenkins A, Truong T, Giunta AL, Blackbeer J, MacIver MB, Harrison NL, Hemmings HC Jr. Lingamaneni R, et al. Among authors: krasowski md. Anesthesiology. 2001 Jun;94(6):1050-7. doi: 10.1097/00000542-200106000-00020. Anesthesiology. 2001. PMID: 11465597 Free article.

10

Intravenous anesthetics differentially modulate ligand-gated ion channels.

Flood P, Krasowski MD. Flood P, et al. Among authors: krasowski md. Anesthesiology. 2000 May;92(5):1418-25. doi: 10.1097/00000542-200005000-00033. Anesthesiology. 2000. PMID: 10781289 Free article.

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