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Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration.
Dziadulewicz EK, Bevan SJ, Brain CT, Coote PR, Culshaw AJ, Davis AJ, Edwards LJ, Fisher AJ, Fox AJ, Gentry C, Groarke A, Hart TW, Huber W, James IF, Kesingland A, La Vecchia L, Loong Y, Lyothier I, McNair K, O'Farrell C, Peacock M, Portmann R, Schopfer U, Yaqoob M, Zadrobilek J. Dziadulewicz EK, et al. Among authors: james if. J Med Chem. 2007 Aug 9;50(16):3851-6. doi: 10.1021/jm070317a. Epub 2007 Jul 14. J Med Chem. 2007. PMID: 17630726
Pharmacological differences between the human and rat vanilloid receptor 1 (VR1).
McIntyre P, McLatchie LM, Chambers A, Phillips E, Clarke M, Savidge J, Toms C, Peacock M, Shah K, Winter J, Weerasakera N, Webb M, Rang HP, Bevan S, James IF. McIntyre P, et al. Among authors: james if. Br J Pharmacol. 2001 Mar;132(5):1084-94. doi: 10.1038/sj.bjp.0703918. Br J Pharmacol. 2001. PMID: 11226139 Free PMC article.
653 results