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Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation. A study with m3 muscarinic receptor point mutants.
Wess J, Maggio R, Palmer JR, Vogel Z. Wess J, et al. J Biol Chem. 1992 Sep 25;267(27):19313-9. J Biol Chem. 1992. PMID: 1527051 Free article.
Structure-function relationship studies of the m3 muscarinic acetylcholine receptor have recently identified a series of threonine and tyrosine residues (all located within the hydrophobic receptor core) that are critically involved in acetylcholine binding (Wess, J
Structure-function relationship studies of the m3 muscarinic acetylcholine receptor have recently identified a series of threonine and tyros …
Mutational analysis of the relative orientation of transmembrane helices I and VII in G protein-coupled receptors.
Liu J, Schöneberg T, van Rhee M, Wess J. Liu J, et al. Among authors: wess j. J Biol Chem. 1995 Aug 18;270(33):19532-9. doi: 10.1074/jbc.270.33.19532. J Biol Chem. 1995. PMID: 7642637 Free article.
We demonstrated previously that hybrid m2/m5 muscarinic acetylcholine receptors which contain m5 sequence in TM I and m2 sequence in TM VII were unable to bind significant amounts of muscarinic radioligands (Pittel, Z., and Wess, J. (1994) Mol. Pharmacol. 45, 61-64) …
We demonstrated previously that hybrid m2/m5 muscarinic acetylcholine receptors which contain m5 sequence in TM I and m2 sequence in TM VII …
Functional role of a cytoplasmic aromatic amino acid in muscarinic receptor-mediated activation of phospholipase C.
Blüml K, Mutschler E, Wess J. Blüml K, et al. Among authors: wess j. J Biol Chem. 1994 Apr 15;269(15):11537-41. J Biol Chem. 1994. PMID: 8157684 Free article.
Using the rat m3 muscarinic receptor as a model system, we have recently demonstrated that a tyrosine residue (Tyr-254), located at the beginning of the i3 domain, is critically involved in muscarinic receptor-mediated stimulation of phosphatidylinositol (PI) hydrolysis (Bluml, K …
Using the rat m3 muscarinic receptor as a model system, we have recently demonstrated that a tyrosine residue (Tyr-254), located at the begi …
355 results