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Spectral karyotyping and fluorescence in situ hybridization detect novel chromosomal aberrations, a recurring involvement of chromosome 21 and amplification of the MYC oncogene in acute myeloid leukaemia M2.
Hilgenfeld E, Padilla-Nash H, McNeil N, Knutsen T, Montagna C, Tchinda J, Horst J, Ludwig WD, Serve H, Büchner T, Berdel WE, Schröck E, Ried T. Hilgenfeld E, et al. Br J Haematol. 2001 May;113(2):305-17. doi: 10.1046/j.1365-2141.2001.02723.x. Br J Haematol. 2001. PMID: 11380393 Free article.
Spectral karyotyping in cancer cytogenetics.
Hilgenfeld E, Montagna C, Padilla-Nash H, Stapleton L, Heselmeyer-Haddad K, Ried T. Hilgenfeld E, et al. Methods Mol Med. 2002;68:29-44. doi: 10.1385/1-59259-135-3:029. Methods Mol Med. 2002. PMID: 11901510 No abstract available.
Analysis of B-cell neoplasias by spectral karyotyping (SKY).
Hilgenfeld E, Padilla-Nash H, Schröck E, Ried T. Hilgenfeld E, et al. Curr Top Microbiol Immunol. 1999;246:169-74. doi: 10.1007/978-3-642-60162-0_21. Curr Top Microbiol Immunol. 1999. PMID: 10396053 Review.
Multicolor karyotyping in acute myeloid leukemia.
Tchinda J, Volpert S, McNeil N, Neumann T, Kennerknecht I, Ried T, Büchner T, Serve H, Berdel WE, Horst J, Hilgenfeld E. Tchinda J, et al. Among authors: hilgenfeld e. Leuk Lymphoma. 2003 Nov;44(11):1843-53. doi: 10.1080/10428190310001603605. Leuk Lymphoma. 2003. PMID: 14738135 Review.
Spectral Karyotyping (SKY) of Hematologic Malignancies.
Hilgenfeld E, Padilla-Nash H, Schröck E, Ried T, Haas OA, Serve H. Hilgenfeld E, et al. Methods Mol Med. 2001;55:65-79. doi: 10.1385/1-59259-074-8:65. Methods Mol Med. 2001. PMID: 21312104
MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site.
Slater DJ, Hilgenfeld E, Rappaport EF, Shah N, Meek RG, Williams WR, Lovett BD, Osheroff N, Autar RS, Ried T, Felix CA. Slater DJ, et al. Among authors: hilgenfeld e. Oncogene. 2002 Jul 11;21(30):4706-14. doi: 10.1038/sj.onc.1205572. Oncogene. 2002. PMID: 12096348
Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing.
Whitmarsh RJ, Saginario C, Zhuo Y, Hilgenfeld E, Rappaport EF, Megonigal MD, Carroll M, Liu M, Osheroff N, Cheung NK, Slater DJ, Ried T, Knutsen T, Blair IA, Felix CA. Whitmarsh RJ, et al. Among authors: hilgenfeld e. Oncogene. 2003 Nov 20;22(52):8448-59. doi: 10.1038/sj.onc.1207052. Oncogene. 2003. PMID: 14627986
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