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A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity.
Bonafè M, Olivieri F, Cavallone L, Giovagnetti S, Mayegiani F, Cardelli M, Pieri C, Marra M, Antonicelli R, Lisa R, Rizzo MR, Paolisso G, Monti D, Franceschi C. Bonafè M, et al. Among authors: pieri c. Eur J Immunol. 2001 Aug;31(8):2357-61. doi: 10.1002/1521-4141(200108)31:8<2357::aid-immu2357>3.0.co;2-x. Eur J Immunol. 2001. PMID: 11500818 Free article.
Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians.
Bonafè M, Marchegiani F, Cardelli M, Olivieri F, Cavallone L, Giovagnetti S, Pieri C, Marra M, Antonicelli R, Troiano L, Gueresi P, Passeri G, Berardelli M, Paolisso G, Barbieri M, Tesei S, Lisa R, De Benedictis G, Franceschi C. Bonafè M, et al. Among authors: pieri c. Eur J Hum Genet. 2002 May;10(5):292-6. doi: 10.1038/sj.ejhg.5200806. Eur J Hum Genet. 2002. PMID: 12082503
141 results