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Enhanced biological activity of 1alpha,25-dihydroxy-20-epi-vitamin D3, the C-20 epimer of 1alpha,25-dihydroxyvitamin D3, is in part due to its metabolism into stable intermediary metabolites with significant biological activity.
Siu-Caldera ML, Sekimoto H, Peleg S, Nguyen C, Kissmeyer AM, Binderup L, Weiskopf A, Vouros P, Uskoković MR, Reddy GS. Siu-Caldera ML, et al. Among authors: peleg s. J Steroid Biochem Mol Biol. 1999 Dec 15;71(3-4):111-21. doi: 10.1016/s0960-0760(99)00130-2. J Steroid Biochem Mol Biol. 1999. PMID: 10659699
1alpha,25-dihydroxy-24-oxo-16-ene vitamin D3, a metabolite of a synthetic vitamin D3 analog, 1alpha,25-dihydroxy-16-ene vitamin D3, is equipotent to its parent in modulating growth and differentiation of human leukemic cells.
Siu-Caldera ML, Clark JW, Santos-Moore A, Peleg S, Liu YY, Uskoković MR, Sharma S, Reddy GS. Siu-Caldera ML, et al. Among authors: peleg s. J Steroid Biochem Mol Biol. 1996 Dec;59(5-6):405-12. doi: 10.1016/s0960-0760(96)00134-3. J Steroid Biochem Mol Biol. 1996. PMID: 9010346
Synthesis and biological activities of the two C(23) epimers of 1alpha,23,25-trihydroxy-24-oxo-19-nor-vitamin D(3): novel analogs of 1alpha,23(S),25-trihydroxy-24-oxo-vitamin D(3), a natural metabolite of 1alpha,25-dihydroxyvitamin D(3).
Lee NE, Williard PG, Brown AJ, Campbell MJ, Koeffler HP, Peleg S, Rao DS, Reddy GS. Lee NE, et al. Among authors: peleg s. Steroids. 2000 May;65(5):252-65. doi: 10.1016/s0039-128x(99)00110-5. Steroids. 2000. PMID: 10751637
190 results