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Page 1
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice.
Podsypanina K, Lee RT, Politis C, Hennessy I, Crane A, Puc J, Neshat M, Wang H, Yang L, Gibbons J, Frost P, Dreisbach V, Blenis J, Gaciong Z, Fisher P, Sawyers C, Hedrick-Ellenson L, Parsons R. Podsypanina K, et al. Among authors: puc j. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10320-5. doi: 10.1073/pnas.171060098. Epub 2001 Aug 14. Proc Natl Acad Sci U S A. 2001. PMID: 11504907 Free PMC article.
Lack of PTEN sequesters CHK1 and initiates genetic instability.
Puc J, Keniry M, Li HS, Pandita TK, Choudhury AD, Memeo L, Mansukhani M, Murty VV, Gaciong Z, Meek SE, Piwnica-Worms H, Hibshoosh H, Parsons R. Puc J, et al. Cancer Cell. 2005 Feb;7(2):193-204. doi: 10.1016/j.ccr.2005.01.009. Cancer Cell. 2005. PMID: 15710331 Free article.
Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair.
Gupta A, Yang Q, Pandita RK, Hunt CR, Xiang T, Misri S, Zeng S, Pagan J, Jeffery J, Puc J, Kumar R, Feng Z, Powell SN, Bhat A, Yaguchi T, Wadhwa R, Kaul SC, Parsons R, Khanna KK, Pandita TK. Gupta A, et al. Among authors: puc j. Cell Cycle. 2009 Jul 15;8(14):2198-210. doi: 10.4161/cc.8.14.8947. Epub 2009 Jul 7. Cell Cycle. 2009. PMID: 19502790 Free article.
24 results