Flores JM - Search Results

1

Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.

Samper E, Flores JM, Blasco MA. Samper E, et al. Among authors: flores jm. EMBO Rep. 2001 Sep;2(9):800-7. doi: 10.1093/embo-reports/kve174. Epub 2001 Aug 23. EMBO Rep. 2001. PMID: 11520856 Free PMC article.

2

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally.

García-Cao I, García-Cao M, Martín-Caballero J, Criado LM, Klatt P, Flores JM, Weill JC, Blasco MA, Serrano M. García-Cao I, et al. Among authors: flores jm. EMBO J. 2002 Nov 15;21(22):6225-35. doi: 10.1093/emboj/cdf595. EMBO J. 2002. PMID: 12426394 Free PMC article.

3

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.

Espejel S, Martín M, Klatt P, Martín-Caballero J, Flores JM, Blasco MA. Espejel S, et al. Among authors: flores jm. EMBO Rep. 2004 May;5(5):503-9. doi: 10.1038/sj.embor.7400127. Epub 2004 Apr 23. EMBO Rep. 2004. PMID: 15105825 Free PMC article.

4

Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice.

González-Suárez E, Geserick C, Flores JM, Blasco MA. González-Suárez E, et al. Among authors: flores jm. Oncogene. 2005 Mar 24;24(13):2256-70. doi: 10.1038/sj.onc.1208413. Oncogene. 2005. PMID: 15688016

5

The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression.

Cayuela ML, Flores JM, Blasco MA. Cayuela ML, et al. Among authors: flores jm. EMBO Rep. 2005 Mar;6(3):268-74. doi: 10.1038/sj.embor.7400359. EMBO Rep. 2005. PMID: 15731767 Free PMC article.

6

Increased p53 activity does not accelerate telomere-driven ageing.

García-Cao I, García-Cao M, Tomás-Loba A, Martín-Caballero J, Flores JM, Klatt P, Blasco MA, Serrano M. García-Cao I, et al. Among authors: flores jm. EMBO Rep. 2006 May;7(5):546-52. doi: 10.1038/sj.embor.7400667. Epub 2006 Mar 31. EMBO Rep. 2006. PMID: 16582880 Free PMC article.

7

MSH2 deficiency abolishes the anticancer and pro-aging activity of short telomeres.

Martinez P, Siegl-Cachedenier I, Flores JM, Blasco MA. Martinez P, et al. Among authors: flores jm. Aging Cell. 2009 Feb;8(1):2-17. doi: 10.1111/j.1474-9726.2008.00441.x. Aging Cell. 2009. PMID: 18986375 Free article.

8

The rate of increase of short telomeres predicts longevity in mammals.

Vera E, Bernardes de Jesus B, Foronda M, Flores JM, Blasco MA. Vera E, et al. Among authors: flores jm. Cell Rep. 2012 Oct 25;2(4):732-7. doi: 10.1016/j.celrep.2012.08.023. Epub 2012 Sep 27. Cell Rep. 2012. PMID: 23022483 Free article.

9

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres.

Herrera E, Samper E, Martín-Caballero J, Flores JM, Lee HW, Blasco MA. Herrera E, et al. Among authors: flores jm. EMBO J. 1999 Jun 1;18(11):2950-60. doi: 10.1093/emboj/18.11.2950. EMBO J. 1999. PMID: 10357808 Free PMC article.

10

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

González-Suárez E, Samper E, Flores JM, Blasco MA. González-Suárez E, et al. Among authors: flores jm. Nat Genet. 2000 Sep;26(1):114-7. doi: 10.1038/79089. Nat Genet. 2000. PMID: 10973262

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