Hallgren KW - Search Results

1

Identification of sequences within the gamma-carboxylase that represent a novel contact site with vitamin K-dependent proteins and that are required for activity.

Pudota BN, Hommema EL, Hallgren KW, McNally BA, Lee S, Berkner KL. Pudota BN, et al. Among authors: hallgren kw. J Biol Chem. 2001 Dec 14;276(50):46878-86. doi: 10.1074/jbc.M108696200. Epub 2001 Oct 8. J Biol Chem. 2001. PMID: 11591726 Free article.

2

Carboxylase overexpression effects full carboxylation but poor release and secretion of factor IX: implications for the release of vitamin K-dependent proteins.

Hallgren KW, Hommema EL, McNally BA, Berkner KL. Hallgren KW, et al. Biochemistry. 2002 Dec 17;41(50):15045-55. doi: 10.1021/bi026016e. Biochemistry. 2002. PMID: 12475254

3

A new model for vitamin K-dependent carboxylation: the catalytic base that deprotonates vitamin K hydroquinone is not Cys but an activated amine.

Rishavy MA, Pudota BN, Hallgren KW, Qian W, Yakubenko AV, Song JH, Runge KW, Berkner KL. Rishavy MA, et al. Among authors: hallgren kw. Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13732-7. doi: 10.1073/pnas.0404989101. Epub 2004 Sep 13. Proc Natl Acad Sci U S A. 2004. PMID: 15365175 Free PMC article.

4

The vitamin K-dependent carboxylase has been acquired by Leptospira pathogens and shows altered activity that suggests a role other than protein carboxylation.

Rishavy MA, Hallgren KW, Yakubenko AV, Zuerner RL, Runge KW, Berkner KL. Rishavy MA, et al. Among authors: hallgren kw. J Biol Chem. 2005 Oct 14;280(41):34870-7. doi: 10.1074/jbc.M504345200. Epub 2005 Aug 1. J Biol Chem. 2005. PMID: 16061481 Free article.

5

Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation.

Rishavy MA, Usubalieva A, Hallgren KW, Berkner KL. Rishavy MA, et al. Among authors: hallgren kw. J Biol Chem. 2011 Mar 4;286(9):7267-78. doi: 10.1074/jbc.M110.172213. Epub 2010 Oct 26. J Biol Chem. 2011. PMID: 20978134 Free PMC article.

6

The vitamin K-dependent carboxylase generates γ-carboxylated glutamates by using CO2 to facilitate glutamate deprotonation in a concerted mechanism that drives catalysis.

Rishavy MA, Hallgren KW, Berkner KL. Rishavy MA, et al. Among authors: hallgren kw. J Biol Chem. 2011 Dec 30;286(52):44821-32. doi: 10.1074/jbc.M111.249177. Epub 2011 Sep 6. J Biol Chem. 2011. PMID: 21896484 Free PMC article.

7

Identification of the vitamin K-dependent carboxylase active site: Cys-99 and Cys-450 are required for both epoxidation and carboxylation.

Pudota BN, Miyagi M, Hallgren KW, West KA, Crabb JW, Misono KS, Berkner KL. Pudota BN, et al. Among authors: hallgren kw. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13033-8. doi: 10.1073/pnas.97.24.13033. Proc Natl Acad Sci U S A. 2000. PMID: 11087858 Free PMC article.

8

Methylation of γ-carboxylated Glu (Gla) allows detection by liquid chromatography-mass spectrometry and the identification of Gla residues in the γ-glutamyl carboxylase.

Hallgren KW, Zhang D, Kinter M, Willard B, Berkner KL. Hallgren KW, et al. J Proteome Res. 2013 Jun 7;12(6):2365-74. doi: 10.1021/pr3003722. Epub 2013 May 10. J Proteome Res. 2013. PMID: 22536908 Free PMC article.

9

r-VKORC1 expression in factor IX BHK cells increases the extent of factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate-limiting step.

Hallgren KW, Qian W, Yakubenko AV, Runge KW, Berkner KL. Hallgren KW, et al. Biochemistry. 2006 May 2;45(17):5587-98. doi: 10.1021/bi051986y. Biochemistry. 2006. PMID: 16634640 Free PMC article.

10

Brønsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation.

Rishavy MA, Hallgren KW, Yakubenko AV, Shtofman RL, Runge KW, Berkner KL. Rishavy MA, et al. Among authors: hallgren kw. Biochemistry. 2006 Nov 7;45(44):13239-48. doi: 10.1021/bi0609523. Biochemistry. 2006. PMID: 17073445

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