Boyd HF - Search Results

1

Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones.

Boyd HF, Fell SC, Hickey DM, Ife RJ, Leach CA, Macphee CH, Milliner KJ, Pinto IL, Rawlings DA, Smith SA, Stansfield IG, Stanway SJ, Theobald CJ, Whittaker CM. Boyd HF, et al. Bioorg Med Chem Lett. 2002 Jan 7;12(1):51-5. doi: 10.1016/s0960-894x(01)00678-3. Bioorg Med Chem Lett. 2002. PMID: 11738571

2

2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2.

Boyd HF, Flynn ST, Hickey DM, Ife RJ, Jones M, Leach CA, Macphee CH, Milliner KJ, Rawlings DA, Slingsby BP, Smith SA, Stansfield IG, Tew DG, Theobald CJ. Boyd HF, et al. Bioorg Med Chem Lett. 2000 Feb 21;10(4):395-8. doi: 10.1016/s0960-894x(00)00002-0. Bioorg Med Chem Lett. 2000. PMID: 10714508

3

Natural product derived inhibitors of lipoprotein associated phospholipase A2, synthesis and activity of analogues of SB-253514.

Pinto IL, Boyd HF, Hickey DM. Pinto IL, et al. Among authors: boyd hf. Bioorg Med Chem Lett. 2000 Sep 4;10(17):2015-7. doi: 10.1016/s0960-894x(00)00395-4. Bioorg Med Chem Lett. 2000. PMID: 10987439

4

N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2.

Boyd HF, Fell SC, Flynn ST, Hickey DM, Ife RJ, Leach CA, Macphee CH, Milliner KJ, Moores KE, Pinto IL, Porter RA, Rawlings DA, Smith SA, Stansfield IG, Tew DG, Theobald CJ, Whittaker CM. Boyd HF, et al. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2557-61. doi: 10.1016/s0960-894x(00)00510-2. Bioorg Med Chem Lett. 2000. PMID: 11086729

5

The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2.

Boyd HF, Hammond B, Hickey DM, Ife RJ, Leach CA, Lewis VA, Macphee CH, Milliner KJ, Pinto IL, Smith SA, Stansfield IG, Theobald CJ, Whittaker CM. Boyd HF, et al. Bioorg Med Chem Lett. 2001 Mar 12;11(5):701-4. doi: 10.1016/s0960-894x(01)00038-5. Bioorg Med Chem Lett. 2001. PMID: 11266173

6

1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A(2).

Bloomer JC, Boyd HF, Hickey DM, Ife RJ, Leach CA, Macphee CH, Milliner KJ, Pinto IL, Rawlings DA, Smith SA, Stansfield IG, Stanway SJ, Taylor MA, Theobald CJ, Whittaker CM. Bloomer JC, et al. Among authors: boyd hf. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1925-9. doi: 10.1016/s0960-894x(01)00346-8. Bioorg Med Chem Lett. 2001. PMID: 11459662

7

Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor.

MacPhee CH, Moores KE, Boyd HF, Dhanak D, Ife RJ, Leach CA, Leake DS, Milliner KJ, Patterson RA, Suckling KE, Tew DG, Hickey DM. MacPhee CH, et al. Among authors: boyd hf. Biochem J. 1999 Mar 1;338 ( Pt 2)(Pt 2):479-87. Biochem J. 1999. PMID: 10024526 Free PMC article.

8

ATP-Citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and evaluation of (3R,5S)-omega-substituted-3-carboxy-3, 5-dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzyme in vitro and in vivo.

Gribble AD, Ife RJ, Shaw A, McNair D, Novelli CE, Bakewell S, Shah VP, Dolle RE, Groot PH, Pearce N, Yates J, Tew D, Boyd H, Ashman S, Eggleston DS, Haltiwanger RC, Okafo G. Gribble AD, et al. J Med Chem. 1998 Sep 10;41(19):3582-95. doi: 10.1021/jm980091z. J Med Chem. 1998. PMID: 9733484

9

Mechanism of inhibition of LDL phospholipase A2 by monocyclic-beta-lactams. Burst kinetics and the effect of stereochemistry.

Tew DG, Boyd HF, Ashman S, Theobald C, Leach CA. Tew DG, et al. Among authors: boyd hf. Biochemistry. 1998 Jul 14;37(28):10087-93. doi: 10.1021/bi9801412. Biochemistry. 1998. PMID: 9665713

10

Purification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins.

Tew DG, Southan C, Rice SQ, Lawrence MP, Li H, Boyd HF, Moores K, Gloger IS, Macphee CH. Tew DG, et al. Among authors: boyd hf. Arterioscler Thromb Vasc Biol. 1996 Apr;16(4):591-9. doi: 10.1161/01.atv.16.4.591. Arterioscler Thromb Vasc Biol. 1996. PMID: 8624782

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