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Page 1
Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs.
Hay DW, Giardina GA, Griswold DE, Underwood DC, Kotzer CJ, Bush B, Potts W, Sandhu P, Lundberg D, Foley JJ, Schmidt DB, Martin LD, Kilian D, Legos JJ, Barone FC, Luttmann MA, Grugni M, Raveglia LF, Sarau HM. Hay DW, et al. Among authors: potts w. J Pharmacol Exp Ther. 2002 Jan;300(1):314-23. doi: 10.1124/jpet.300.1.314. J Pharmacol Exp Ther. 2002. PMID: 11752131
Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist.
Sarau HM, Griswold DE, Bush B, Potts W, Sandhu P, Lundberg D, Foley JJ, Schmidt DB, Webb EF, Martin LD, Legos JJ, Whitmore RG, Barone FC, Medhurst AD, Luttmann MA, Giardina GA, Hay DW. Sarau HM, et al. Among authors: potts w. J Pharmacol Exp Ther. 2000 Oct;295(1):373-81. J Pharmacol Exp Ther. 2000. PMID: 10992004
Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity.
Albert JS, Aharony D, Andisik D, Barthlow H, Bernstein PR, Bialecki RA, Dedinas R, Dembofsky BT, Hill D, Kirkland K, Koether GM, Kosmider BJ, Ohnmacht C, Palmer W, Potts W, Rumsey W, Shen L, Shenvi A, Sherwood S, Warwick PJ, Russell K. Albert JS, et al. Among authors: potts w. J Med Chem. 2002 Aug 29;45(18):3972-83. doi: 10.1021/jm020094i. J Med Chem. 2002. PMID: 12190319
[11C]AZ10419369: a selective 5-HT1B receptor radioligand suitable for positron emission tomography (PET). Characterization in the primate brain.
Pierson ME, Andersson J, Nyberg S, McCarthy DJ, Finnema SJ, Varnäs K, Takano A, Karlsson P, Gulyás B, Medd AM, Lee CM, Powell ME, Heys JR, Potts W, Seneca N, Mrzljak L, Farde L, Halldin C. Pierson ME, et al. Among authors: potts w. Neuroimage. 2008 Jul 1;41(3):1075-85. doi: 10.1016/j.neuroimage.2008.02.063. Epub 2008 Mar 14. Neuroimage. 2008. PMID: 18434202
Discovery of spirofused piperazine and diazepane amides as selective histamine-3 antagonists with in vivo efficacy in a mouse model of cognition.
Brown DG, Bernstein PR, Griffin A, Wesolowski S, Labrecque D, Tremblay MC, Sylvester M, Mauger R, Edwards PD, Throner SR, Folmer JJ, Cacciola J, Scott C, Lazor LA, Pourashraf M, Santhakumar V, Potts WM, Sydserff S, Giguère P, Lévesque C, Dasser M, Groblewski T. Brown DG, et al. J Med Chem. 2014 Feb 13;57(3):733-58. doi: 10.1021/jm4014828. Epub 2014 Jan 27. J Med Chem. 2014. PMID: 24410637
Discovery of novel, orally active dual NK1/NK2 antagonists.
Bernstein PR, Aharony D, Albert JS, Andisik D, Barthlow HG, Bialecki R, Davenport T, Dedinas RF, Dembofsky BT, Koether G, Kosmider BJ, Kirkland K, Ohnmacht CJ, Potts W, Rumsey WL, Shen L, Shenvi A, Sherwood S, Stollman D, Russell K. Bernstein PR, et al. Among authors: potts w. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2769-73. doi: 10.1016/s0960-894x(01)00572-8. Bioorg Med Chem Lett. 2001. PMID: 11591520
339 results