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308 results

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Page 1
A novel class of endotoxin receptor agonists with simplified structure, toll-like receptor 4-dependent immunostimulatory action, and adjuvant activity.
Hawkins LD, Ishizaka ST, McGuinness P, Zhang H, Gavin W, DeCosta B, Meng Z, Yang H, Mullarkey M, Young DW, Yang H, Rossignol DP, Nault A, Rose J, Przetak M, Chow JC, Gusovsky F. Hawkins LD, et al. Among authors: young dw. J Pharmacol Exp Ther. 2002 Feb;300(2):655-61. doi: 10.1124/jpet.300.2.655. J Pharmacol Exp Ther. 2002. PMID: 11805229 Clinical Trial.
E6201 [(3S,4R,5Z,8S,9S,11E)-14-(ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-1 and MEK kinase-1: in vitro characterization of its anti-inflammatory and antihyperproliferative activities.
Goto M, Chow J, Muramoto K, Chiba K, Yamamoto S, Fujita M, Obaishi H, Tai K, Mizui Y, Tanaka I, Young D, Yang H, Wang YJ, Shirota H, Gusovsky F. Goto M, et al. J Pharmacol Exp Ther. 2009 Nov;331(2):485-95. doi: 10.1124/jpet.109.156554. Epub 2009 Aug 14. J Pharmacol Exp Ther. 2009. PMID: 19684251
The extra domain A of fibronectin activates Toll-like receptor 4.
Okamura Y, Watari M, Jerud ES, Young DW, Ishizaka ST, Rose J, Chow JC, Strauss JF 3rd. Okamura Y, et al. Among authors: young dw. J Biol Chem. 2001 Mar 30;276(13):10229-33. doi: 10.1074/jbc.M100099200. Epub 2001 Jan 9. J Biol Chem. 2001. PMID: 11150311 Free article.
Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology.
Jimmidi R, Monsivais D, Ta HM, Sharma KL, Bohren KM, Chamakuri S, Liao Z, Li F, Hakenjos JM, Li JY, Mishina Y, Pan H, Qin X, Robers MB, Sankaran B, Tan Z, Tang S, Vasquez YM, Wilkinson J, Young DW, Palmer SS, MacKenzie KR, Kim C, Matzuk MM. Jimmidi R, et al. Among authors: young dw. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2413108121. doi: 10.1073/pnas.2413108121. Epub 2024 Nov 14. Proc Natl Acad Sci U S A. 2024. PMID: 39541346
Reversible male contraception by targeted inhibition of serine/threonine kinase 33.
Ku AF, Sharma KL, Ta HM, Sutton CM, Bohren KM, Wang Y, Chamakuri S, Chen R, Hakenjos JM, Jimmidi R, Kent K, Li F, Li JY, Ma L, Madasu C, Palaniappan M, Palmer SS, Qin X, Robers MB, Sankaran B, Tan Z, Vasquez YM, Wang J, Wilkinson J, Yu Z, Ye Q, Young DW, Teng M, Kim C, Matzuk MM. Ku AF, et al. Among authors: young dw. Science. 2024 May 24;384(6698):885-890. doi: 10.1126/science.adl2688. Epub 2024 May 23. Science. 2024. PMID: 38781365
Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology.
Madasu C, Liao Z, Parks SE, Sharma KL, Bohren KM, Ye Q, Li F, Palaniappan M, Tan Z, Yuan F, Creighton CJ, Tang S, Masand RP, Guan X, Young DW, Monsivais D, Matzuk MM. Madasu C, et al. Among authors: young dw. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2322934121. doi: 10.1073/pnas.2322934121. Epub 2024 May 3. Proc Natl Acad Sci U S A. 2024. PMID: 38701119 Free PMC article.
Expanding Complex Morpholines Using Systematic Chemical Diversity.
Tang SA, Fults A, Boyd SR, Gattu N, Tran KA, Fan J, MacKenzie KR, Palzkill T, Young DW, Chamakuri S. Tang SA, et al. Among authors: young dw. Org Lett. 2024 May 3;26(17):3493-3497. doi: 10.1021/acs.orglett.4c00528. Epub 2024 Mar 20. Org Lett. 2024. PMID: 38506470
308 results