Hornberger W - Search Results

1

Synthesis and SAR of N-substituted dibenzazepinone derivatives as novel potent and selective alpha(V)beta(3) antagonists.

Kling A, Backfisch G, Delzer J, Geneste H, Graef C, Holzenkamp U, Hornberger W, Lange UE, Lauterbach A, Mack H, Seitz W, Subkowski T. Kling A, et al. Among authors: hornberger w. Bioorg Med Chem Lett. 2002 Feb 11;12(3):441-6. doi: 10.1016/s0960-894x(01)00773-9. Bioorg Med Chem Lett. 2002. PMID: 11814816

2

Synthesis of highly potent and selective hetaryl ureas as integrin alpha(V)beta3-receptor antagonists.

Lange UE, Backfisch G, Delzer J, Geneste H, Graef C, Hornberger W, Kling A, Lauterbach A, Subkowski T, Zechel C. Lange UE, et al. Among authors: hornberger w. Bioorg Med Chem Lett. 2002 May 20;12(10):1379-82. doi: 10.1016/s0960-894x(02)00161-0. Bioorg Med Chem Lett. 2002. PMID: 11992781

3

Highly potent and selective alphaVbeta3-receptor antagonists: solid-phase synthesis and SAR of 1-substituted 4-amino-1H-pyrimidin-2-ones.

Zechel C, Backfisch G, Delzer J, Geneste H, Graef C, Hornberger W, Kling A, Lange UE, Lauterbach A, Seitz W, Subkowski T. Zechel C, et al. Among authors: hornberger w. Bioorg Med Chem Lett. 2003 Jan 20;13(2):165-9. doi: 10.1016/s0960-894x(02)00931-9. Bioorg Med Chem Lett. 2003. PMID: 12482416

4

Design and synthesis of 1,5- and 2,5-substituted tetrahydrobenzazepinones as novel potent and selective integrin alphaVbeta3 antagonists.

Kling A, Backfisch G, Delzer J, Geneste H, Graef C, Hornberger W, Lange UE, Lauterbach A, Seitz W, Subkowski T. Kling A, et al. Among authors: hornberger w. Bioorg Med Chem. 2003 Apr 3;11(7):1319-41. doi: 10.1016/s0968-0896(02)00616-8. Bioorg Med Chem. 2003. PMID: 12628659

5

D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety.

Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Höffken HW. Lange UE, et al. Among authors: hornberger w. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2029-33. doi: 10.1016/s0960-894x(03)00347-0. Bioorg Med Chem Lett. 2003. PMID: 12781189

6

Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs.

Kling A, Lange UE, Mack H, Bakker MH, Drescher KU, Hornberger W, Hutchins CW, Möller A, Müller R, Schmidt M, Unger L, Wicke K, Schellhaas K, Steiner G. Kling A, et al. Among authors: hornberger w. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5567-73. doi: 10.1016/j.bmcl.2005.04.077. Epub 2005 Oct 10. Bioorg Med Chem Lett. 2005. PMID: 16219465

7

Orally active thrombin inhibitors. Part 2: optimization of the P2-moiety.

Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Höffken HW. Lange UE, et al. Among authors: hornberger w. Bioorg Med Chem Lett. 2006 May 15;16(10):2648-53. doi: 10.1016/j.bmcl.2006.01.046. Epub 2006 Feb 3. Bioorg Med Chem Lett. 2006. PMID: 16460939

8

Orally active thrombin inhibitors. Part 1: optimization of the P1-moiety.

Mack H, Baucke D, Hornberger W, Lange UE, Seitz W, Höffken HW. Mack H, et al. Among authors: hornberger w. Bioorg Med Chem Lett. 2006 May 15;16(10):2641-7. doi: 10.1016/j.bmcl.2006.02.040. Epub 2006 Mar 6. Bioorg Med Chem Lett. 2006. PMID: 16517159

9

Design and synthesis of novel potent and selective integrin alphanubeta3 antagonists--novel synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates.

Seitz W, Geneste H, Backfisch G, Delzer J, Graef C, Hornberger W, Kling A, Subkowski T, Zimmermann N. Seitz W, et al. Among authors: hornberger w. Bioorg Med Chem Lett. 2008 Jan 15;18(2):527-31. doi: 10.1016/j.bmcl.2007.11.089. Epub 2007 Nov 28. Bioorg Med Chem Lett. 2008. PMID: 18068982

10

Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties.

Oost T, Backfisch G, Bhowmik S, van Gaalen MM, Geneste H, Hornberger W, Lubisch W, Netz A, Unger L, Wernet W. Oost T, et al. Among authors: hornberger w. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3828-31. doi: 10.1016/j.bmcl.2011.03.012. Epub 2011 Mar 6. Bioorg Med Chem Lett. 2011. PMID: 21605973

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