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Design, synthesis, and analysis of a polyethelene glycol-modified (PEGylated) small molecule inhibitor of integrin {alpha}4{beta}1 with improved pharmaceutical properties.
Pepinsky RB, Lee WC, Cornebise M, Gill A, Wortham K, Chen LL, Leone DR, Giza K, Dolinski BM, Perper S, Nickerson-Nutter C, Lepage D, Chakraborty A, Whalley ET, Petter RC, Adams SP, Lobb RR, Scott DM. Pepinsky RB, et al. Among authors: chakraborty a. J Pharmacol Exp Ther. 2005 Feb;312(2):742-50. doi: 10.1124/jpet.104.075648. Epub 2004 Oct 14. J Pharmacol Exp Ther. 2005. PMID: 15485895
Proteolethargy is a pathogenic mechanism in chronic disease.
Dall'Agnese A, Zheng MM, Moreno S, Platt JM, Hoang AT, Kannan D, Dall'Agnese G, Overholt KJ, Sagi I, Hannett NM, Erb H, Corradin O, Chakraborty AK, Lee TI, Young RA. Dall'Agnese A, et al. Among authors: chakraborty ak. Cell. 2024 Nov 25:S0092-8674(24)01274-1. doi: 10.1016/j.cell.2024.10.051. Online ahead of print. Cell. 2024. PMID: 39610243
F2,6BP restores mitochondrial genome integrity in Huntington's Disease.
Chakraborty A, Mandal SM, Mankevich M, Sreenivasmurthy SG, Hegde ML, Krishnan B, Ghosh G, Hazra T. Chakraborty A, et al. bioRxiv [Preprint]. 2024 Nov 4:2024.11.04.621834. doi: 10.1101/2024.11.04.621834. bioRxiv. 2024. PMID: 39574700 Free PMC article. Preprint.
2,610 results