Bohets H - Search Results

1

Rapid permeability screening in drug discovery to predict human intestinal absorption.

Mannens GS, Bohets H, Verboven P, Steemans K, Lavrijsen K, Meuldermans W. Mannens GS, et al. Among authors: bohets h. Ernst Schering Res Found Workshop. 2002;(37):49-67. doi: 10.1007/978-3-662-04383-7_3. Ernst Schering Res Found Workshop. 2002. PMID: 11975200 Review. No abstract available.

2

Strategies for absorption screening in drug discovery and development.

Bohets H, Annaert P, Mannens G, Van Beijsterveldt L, Anciaux K, Verboven P, Meuldermans W, Lavrijsen K. Bohets H, et al. Curr Top Med Chem. 2001 Nov;1(5):367-83. doi: 10.2174/1568026013394886. Curr Top Med Chem. 2001. PMID: 11899103 Review.

3

Identification of the cytochrome P450 enzymes involved in the metabolism of cisapride: in vitro studies of potential co-medication interactions.

Bohets H, Lavrijsen K, Hendrickx J, van Houdt J, van Genechten V, Verboven P, Meuldermans W, Heykants J. Bohets H, et al. Br J Pharmacol. 2000 Apr;129(8):1655-67. doi: 10.1038/sj.bjp.0703246. Br J Pharmacol. 2000. PMID: 10780971 Free PMC article.

4

Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans.

Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M. Paulussen A, et al. Among authors: bohets h. Pharmacogenetics. 2000 Jul;10(5):415-24. doi: 10.1097/00008571-200007000-00005. Pharmacogenetics. 2000. PMID: 10898111

5

Fast monolithic micellar liquid chromatography: an alternative drug permeability assessing method for high-throughput screening.

Detroyer A, Stokbroekx S, Bohets H, Lorreyne W, Timmerman P, Verboven P, Massart DL, Vander Heyden Y. Detroyer A, et al. Among authors: bohets h. Anal Chem. 2004 Dec 15;76(24):7304-9. doi: 10.1021/ac048944k. Anal Chem. 2004. PMID: 15595873

6

Clinical pharmacology of alcaftadine, a novel antihistamine for the prevention of allergic conjunctivitis.

Bohets H, McGowan C, Mannens G, Schroeder N, Edwards-Swanson K, Shapiro A. Bohets H, et al. J Ocul Pharmacol Ther. 2011 Apr;27(2):187-95. doi: 10.1089/jop.2010.0153. Epub 2011 Feb 12. J Ocul Pharmacol Ther. 2011. PMID: 21314437 Clinical Trial.

7

In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

Janssen PA, Lewi PJ, Arnold E, Daeyaert F, de Jonge M, Heeres J, Koymans L, Vinkers M, Guillemont J, Pasquier E, Kukla M, Ludovici D, Andries K, de Béthune MP, Pauwels R, Das K, Clark AD Jr, Frenkel YV, Hughes SH, Medaer B, De Knaep F, Bohets H, De Clerck F, Lampo A, Williams P, Stoffels P. Janssen PA, et al. Among authors: bohets h. J Med Chem. 2005 Mar 24;48(6):1901-9. doi: 10.1021/jm040840e. J Med Chem. 2005. PMID: 15771434 Review.

8

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes.

Bahadur N, Leathart JB, Mutch E, Steimel-Crespi D, Dunn SA, Gilissen R, Houdt JV, Hendrickx J, Mannens G, Bohets H, Williams FM, Armstrong M, Crespi CL, Daly AK. Bahadur N, et al. Among authors: bohets h. Biochem Pharmacol. 2002 Dec 1;64(11):1579-89. doi: 10.1016/s0006-2952(02)01354-0. Biochem Pharmacol. 2002. PMID: 12429347

9

Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds.

Lewi P, Arnold E, Andries K, Bohets H, Borghys H, Clark A, Daeyaert F, Das K, de Béthune MP, de Jonge M, Heeres J, Koymans L, Leempoels J, Peeters J, Timmerman P, Van den Broeck W, Vanhoutte F, Van't Klooster G, Vinkers M, Volovik Y, Janssen PA. Lewi P, et al. Among authors: bohets h. Drugs R D. 2004;5(5):245-57. doi: 10.2165/00126839-200405050-00001. Drugs R D. 2004. PMID: 15357624

10

The c-Met Tyrosine Kinase Inhibitor JNJ-38877605 Causes Renal Toxicity through Species-Specific Insoluble Metabolite Formation.

Lolkema MP, Bohets HH, Arkenau HT, Lampo A, Barale E, de Jonge MJA, van Doorn L, Hellemans P, de Bono JS, Eskens FALM. Lolkema MP, et al. Among authors: bohets hh. Clin Cancer Res. 2015 May 15;21(10):2297-2304. doi: 10.1158/1078-0432.CCR-14-3258. Epub 2015 Mar 5. Clin Cancer Res. 2015. PMID: 25745036 Free PMC article. Clinical Trial.

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