Jarvest RL - Search Results

1

Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.

Jarvest RL, Berge JM, Berry V, Boyd HF, Brown MJ, Elder JS, Forrest AK, Fosberry AP, Gentry DR, Hibbs MJ, Jaworski DD, O'Hanlon PJ, Pope AJ, Rittenhouse S, Sheppard RJ, Slater-Radosti C, Worby A. Jarvest RL, et al. J Med Chem. 2002 May 9;45(10):1959-62. doi: 10.1021/jm025502x. J Med Chem. 2002. PMID: 11985462

2

The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.

Brown MJ, Carter PS, Fenwick AS, Fosberry AP, Hamprecht DW, Hibbs MJ, Jarvest RL, Mensah L, Milner PH, O'Hanlon PJ, Pope AJ, Richardson CM, West A, Witty DR. Brown MJ, et al. Among authors: jarvest rl. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3171-4. doi: 10.1016/s0960-894x(02)00604-2. Bioorg Med Chem Lett. 2002. PMID: 12372526

3

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown MJ, Brown P, Elder JS, Forrest AK, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Rittenhouse S, Sheppard RJ. Jarvest RL, et al. Bioorg Med Chem Lett. 2003 Feb 24;13(4):665-8. doi: 10.1016/s0960-894x(02)01027-2. Bioorg Med Chem Lett. 2003. PMID: 12639554

4

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown P, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Pope AJ, Rittenhouse S. Jarvest RL, et al. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1265-8. doi: 10.1016/s0960-894x(03)00093-3. Bioorg Med Chem Lett. 2003. PMID: 12657260

5

Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues.

Jarvest RL, Armstrong SA, Berge JM, Brown P, Elder JS, Brown MJ, Copley RC, Forrest AK, Hamprecht DW, O'Hanlon PJ, Mitchell DJ, Rittenhouse S, Witty DR. Jarvest RL, et al. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3937-41. doi: 10.1016/j.bmcl.2004.05.070. Bioorg Med Chem Lett. 2004. PMID: 15225702

6

Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase.

Jarvest RL, Erskine SG, Forrest AK, Fosberry AP, Hibbs MJ, Jones JJ, O'Hanlon PJ, Sheppard RJ, Worby A. Jarvest RL, et al. Bioorg Med Chem Lett. 2005 May 2;15(9):2305-9. doi: 10.1016/j.bmcl.2005.03.003. Bioorg Med Chem Lett. 2005. PMID: 15837314

7

Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases.

Forrest AK, Jarvest RL, Mensah LM, O'Hanlon PJ, Pope AJ, Sheppard RJ. Forrest AK, et al. Among authors: jarvest rl. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1871-4. doi: 10.1016/s0960-894x(00)00360-7. Bioorg Med Chem Lett. 2000. PMID: 10969988

8

Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383.

Jarvest RL, Berge JM, Brown P, Hamprecht DW, McNair DJ, Mensah L, O'Hanlon PJ, Pope AJ. Jarvest RL, et al. Bioorg Med Chem Lett. 2001 Mar 12;11(5):715-8. doi: 10.1016/s0960-894x(01)00040-3. Bioorg Med Chem Lett. 2001. PMID: 11266176

9

Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of carbocyclic analogues of the natural product SB-219383.

Jarvest RL, Berge JM, Houge-Frydrych CS, Mensah LM, O'Hanlon PJ, Pope AJ. Jarvest RL, et al. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2499-502. doi: 10.1016/s0960-894x(01)00475-9. Bioorg Med Chem Lett. 2001. PMID: 11549455

10

Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes.

Gentry DR, Ingraham KA, Stanhope MJ, Rittenhouse S, Jarvest RL, O'Hanlon PJ, Brown JR, Holmes DJ. Gentry DR, et al. Among authors: jarvest rl. Antimicrob Agents Chemother. 2003 Jun;47(6):1784-9. doi: 10.1128/AAC.47.6.1784-1789.2003. Antimicrob Agents Chemother. 2003. PMID: 12760849 Free PMC article.

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