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Page 1
Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.
Jarvest RL, Berge JM, Berry V, Boyd HF, Brown MJ, Elder JS, Forrest AK, Fosberry AP, Gentry DR, Hibbs MJ, Jaworski DD, O'Hanlon PJ, Pope AJ, Rittenhouse S, Sheppard RJ, Slater-Radosti C, Worby A. Jarvest RL, et al. Among authors: rittenhouse s. J Med Chem. 2002 May 9;45(10):1959-62. doi: 10.1021/jm025502x. J Med Chem. 2002. PMID: 11985462
Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues.
Jarvest RL, Armstrong SA, Berge JM, Brown P, Elder JS, Brown MJ, Copley RC, Forrest AK, Hamprecht DW, O'Hanlon PJ, Mitchell DJ, Rittenhouse S, Witty DR. Jarvest RL, et al. Among authors: rittenhouse s. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3937-41. doi: 10.1016/j.bmcl.2004.05.070. Bioorg Med Chem Lett. 2004. PMID: 15225702
Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes.
Gentry DR, Ingraham KA, Stanhope MJ, Rittenhouse S, Jarvest RL, O'Hanlon PJ, Brown JR, Holmes DJ. Gentry DR, et al. Among authors: rittenhouse s. Antimicrob Agents Chemother. 2003 Jun;47(6):1784-9. doi: 10.1128/AAC.47.6.1784-1789.2003. Antimicrob Agents Chemother. 2003. PMID: 12760849 Free PMC article.
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).
Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF. Heerding DA, et al. Among authors: rittenhouse sf. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2061-5. doi: 10.1016/s0960-894x(01)00404-8. Bioorg Med Chem Lett. 2001. PMID: 11514139
Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents.
Seefeld MA, Miller WH, Newlander KA, Burgess WJ, Payne DJ, Rittenhouse SF, Moore TD, DeWolf WE Jr, Keller PM, Qiu X, Janson CA, Vaidya K, Fosberry AP, Smyth MG, Jaworski DD, Slater-Radosti C, Huffman WF. Seefeld MA, et al. Among authors: rittenhouse sf. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2241-4. doi: 10.1016/s0960-894x(01)00405-x. Bioorg Med Chem Lett. 2001. PMID: 11527706
Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI).
Miller WH, Seefeld MA, Newlander KA, Uzinskas IN, Burgess WJ, Heerding DA, Yuan CC, Head MS, Payne DJ, Rittenhouse SF, Moore TD, Pearson SC, Berry V, DeWolf WE Jr, Keller PM, Polizzi BJ, Qiu X, Janson CA, Huffman WF. Miller WH, et al. Among authors: rittenhouse sf. J Med Chem. 2002 Jul 18;45(15):3246-56. doi: 10.1021/jm020050+. J Med Chem. 2002. PMID: 12109908
Discovery of a novel and potent class of FabI-directed antibacterial agents.
Payne DJ, Miller WH, Berry V, Brosky J, Burgess WJ, Chen E, DeWolf WE Jr, Fosberry AP, Greenwood R, Head MS, Heerding DA, Janson CA, Jaworski DD, Keller PM, Manley PJ, Moore TD, Newlander KA, Pearson S, Polizzi BJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Salyers KL, Seefeld MA, Smyth MG, Takata DT, Uzinskas IN, Vaidya K, Wallis NG, Winram SB, Yuan CC, Huffman WF. Payne DJ, et al. Among authors: rittenhouse sf. Antimicrob Agents Chemother. 2002 Oct;46(10):3118-24. doi: 10.1128/AAC.46.10.3118-3124.2002. Antimicrob Agents Chemother. 2002. PMID: 12234833 Free PMC article.
122 results