Whiteaker KL - Search Results

1

Structure-Activity studies for a novel series of tricyclic dihydropyrimidines as K(ATP) channel openers (KCOs).

Drizin I, Holladay MW, Yi L, Zhang HQ, Gopalakrishnan S, Gopalakrishnan M, Whiteaker KL, Buckner SA, Sullivan JP, Carroll WA. Drizin I, et al. Among authors: whiteaker kl. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1481-4. doi: 10.1016/s0960-894x(02)00207-x. Bioorg Med Chem Lett. 2002. PMID: 12031324

2

Pharmacological characterization of a 1,4-dihydropyridine analogue, 9-(3,4-dichlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione (A-184209) as a novelK(ATP) channel inhibitor.

Gopalakrishnan M, Miller TR, Buckner SA, Milicic I, Molinari EJ, Whiteaker KL, Davis-Taber R, Scott VE, Cassidy C, Sullivan JP, Carroll WA. Gopalakrishnan M, et al. Among authors: whiteaker kl. Br J Pharmacol. 2003 Jan;138(2):393-9. doi: 10.1038/sj.bjp.0705048. Br J Pharmacol. 2003. PMID: 12540531 Free PMC article.

3

[125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding.

Davis-Taber R, Molinari EJ, Altenbach RJ, Whiteaker KL, Shieh CC, Rotert G, Buckner SA, Malysz J, Milicic I, McDermott JS, Gintant GA, Coghlan MJ, Carroll WA, Scott VE, Gopalakrishnan M. Davis-Taber R, et al. Among authors: whiteaker kl. Mol Pharmacol. 2003 Jul;64(1):143-53. doi: 10.1124/mol.64.1.143. Mol Pharmacol. 2003. PMID: 12815170

4

Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.

Perez-Medrano A, Buckner SA, Coghlan MJ, Gregg RJ, Gopalakrishnan M, Kort ME, Lynch JK, Scott VE, Sullivan JP, Whiteaker KL, Carroll WA. Perez-Medrano A, et al. Among authors: whiteaker kl. Bioorg Med Chem Lett. 2004 Jan 19;14(2):397-400. doi: 10.1016/j.bmcl.2003.10.063. Bioorg Med Chem Lett. 2004. PMID: 14698167

5

Structure-activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as K(ATP) channel openers.

Drizin I, Altenbach RJ, Buckner SA, Whiteaker KL, Scott VE, Darbyshire JF, Jayanti V, Henry RF, Coghlan MJ, Gopalakrishnan M, Carroll WA. Drizin I, et al. Among authors: whiteaker kl. Bioorg Med Chem. 2004 Apr 15;12(8):1895-904. doi: 10.1016/j.bmc.2004.01.038. Bioorg Med Chem. 2004. PMID: 15051058

6

Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K(ATP) opener that selectively inhibits spontaneous bladder contractions.

Carroll WA, Altenbach RJ, Bai H, Brioni JD, Brune ME, Buckner SA, Cassidy C, Chen Y, Coghlan MJ, Daza AV, Drizin I, Fey TA, Fitzgerald M, Gopalakrishnan M, Gregg RJ, Henry RF, Holladay MW, King LL, Kort ME, Kym PR, Milicic I, Tang R, Turner SC, Whiteaker KL, Yi L, Zhang H, Sullivan JP. Carroll WA, et al. Among authors: whiteaker kl. J Med Chem. 2004 Jun 3;47(12):3163-79. doi: 10.1021/jm030356w. J Med Chem. 2004. PMID: 15163196

7

Synthesis and structure-activity relationships of a novel series of tricyclic dihydropyridine-based KATP openers that potently inhibit bladder contractions in vitro.

Carroll WA, Agrios KA, Altenbach RJ, Buckner SA, Chen Y, Coghlan MJ, Daza AV, Drizin I, Gopalakrishnan M, Henry RF, Kort ME, Kym PR, Milicic I, Smith JC, Tang R, Turner SC, Whiteaker KL, Zhang H, Sullivan JP. Carroll WA, et al. Among authors: whiteaker kl. J Med Chem. 2004 Jun 3;47(12):3180-92. doi: 10.1021/jm030357o. J Med Chem. 2004. PMID: 15163197

8

In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892.

Gopalakrishnan M, Buckner SA, Shieh CC, Fey T, Fabiyi A, Whiteaker KL, Davis-Taber R, Milicic I, Daza AV, Scott VE, Castle NA, Printzenhoff D, London B, Turner SC, Carroll WA, Sullivan JP, Coghlan MJ, Brune ME. Gopalakrishnan M, et al. Among authors: whiteaker kl. Br J Pharmacol. 2004 Sep;143(1):81-90. doi: 10.1038/sj.bjp.0705908. Epub 2004 Aug 9. Br J Pharmacol. 2004. PMID: 15302680 Free PMC article.

9

Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener.

Altenbach RJ, Brune ME, Buckner SA, Coghlan MJ, Daza AV, Fabiyi A, Gopalakrishnan M, Henry RF, Khilevich A, Kort ME, Milicic I, Scott VE, Smith JC, Whiteaker KL, Carroll WA. Altenbach RJ, et al. Among authors: whiteaker kl. J Med Chem. 2006 Nov 16;49(23):6869-87. doi: 10.1021/jm060549u. J Med Chem. 2006. PMID: 17154517

10

Structure-activity studies of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.

Perez-Medrano A, Brune ME, Buckner SA, Coghlan MJ, Fey TA, Gopalakrishnan M, Gregg RJ, Kort ME, Scott VE, Sullivan JP, Whiteaker KL, Carroll WA. Perez-Medrano A, et al. Among authors: whiteaker kl. J Med Chem. 2007 Nov 29;50(24):6265-73. doi: 10.1021/jm7010194. Epub 2007 Oct 31. J Med Chem. 2007. PMID: 17973362

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