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Methylation of imidazoline related compounds leads to loss of α₂-adrenoceptor affinity. Synthesis and biological evaluation of selective I₁ imidazoline receptor ligands.
Schann S, Greney H, Gasparik V, Dontenwill M, Rascente C, Lacroix G, Monassier L, Bruban V, Feldman J, Ehrhardt JD, Bousquet P. Schann S, et al. Among authors: bruban v. Bioorg Med Chem. 2012 Aug 1;20(15):4710-5. doi: 10.1016/j.bmc.2012.06.008. Epub 2012 Jun 9. Bioorg Med Chem. 2012. PMID: 22750139
Imidazoline receptors: a challenge.
Bousquet P, Bruban V, Schann S, Feldman J. Bousquet P, et al. Among authors: bruban v. Pharm Acta Helv. 2000 Mar;74(2-3):205-9. doi: 10.1016/s0031-6865(99)00051-5. Pharm Acta Helv. 2000. PMID: 10812959 Review.
Synthesis and biological evaluation of pyrrolinic isosteres of rilmenidine. Discovery of cis-/trans-dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)-amine (LNP 509), an I1 imidazoline receptor selective ligand with hypotensive activity.
Schann S, Bruban V, Pompermayer K, Feldman J, Pfeiffer B, Renard P, Scalbert E, Bousquet P, Ehrhardt JD. Schann S, et al. Among authors: bruban v. J Med Chem. 2001 May 10;44(10):1588-93. doi: 10.1021/jm001111b. J Med Chem. 2001. PMID: 11334568
19 results