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Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene.
MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, Gohlke P, Speros SJ, Snyder B, Schaefer J, Bieg S, Jiang J, Ettinger RA, Fuller J, Daniels TL, Pettersson A, Orlebeke K, Birren B, Jacob HJ, Lander ES, Lernmark A. MacMurray AJ, et al. Among authors: lernmark a. Genome Res. 2002 Jul;12(7):1029-39. doi: 10.1101/gr.412702. Genome Res. 2002. PMID: 12097339 Free PMC article.
Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat.
Michalkiewicz M, Michalkiewicz T, Ettinger RA, Rutledge EA, Fuller JM, Moralejo DH, Van Yserloo B, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A. Michalkiewicz M, et al. Among authors: lernmark a. Physiol Genomics. 2004 Oct 4;19(2):228-32. doi: 10.1152/physiolgenomics.00126.2004. Epub 2004 Aug 24. Physiol Genomics. 2004. PMID: 15328390
783 results