O'Rahilly S - Search Results

1

Obesity therapy: altering the energy intake-and-expenditure balance sheet.

Crowley VE, Yeo GS, O'Rahilly S. Crowley VE, et al. Nat Rev Drug Discov. 2002 Apr;1(4):276-86. doi: 10.1038/nrd770. Nat Rev Drug Discov. 2002. PMID: 12120279 Review.

2

Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis.

Lelliott CJ, López M, Curtis RK, Parker N, Laudes M, Yeo G, Jimenez-Liñan M, Grosse J, Saha AK, Wiggins D, Hauton D, Brand MD, O'Rahilly S, Griffin JL, Gibbons GF, Vidal-Puig A. Lelliott CJ, et al. FASEB J. 2005 Jul;19(9):1108-19. doi: 10.1096/fj.04-3196com. FASEB J. 2005. PMID: 15985534

3

Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids.

Coll AP, Challis BG, López M, Piper S, Yeo GS, O'Rahilly S. Coll AP, et al. Diabetes. 2005 Aug;54(8):2269-76. doi: 10.2337/diabetes.54.8.2269. Diabetes. 2005. PMID: 16046291

4

A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance.

Lee YS, Challis BG, Thompson DA, Yeo GS, Keogh JM, Madonna ME, Wraight V, Sims M, Vatin V, Meyre D, Shield J, Burren C, Ibrahim Z, Cheetham T, Swift P, Blackwood A, Hung CC, Wareham NJ, Froguel P, Millhauser GL, O'Rahilly S, Farooqi IS. Lee YS, et al. Cell Metab. 2006 Feb;3(2):135-40. doi: 10.1016/j.cmet.2006.01.006. Cell Metab. 2006. PMID: 16459314 Free article.

5

Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice.

Gray SL, Nora ED, Grosse J, Manieri M, Stoeger T, Medina-Gomez G, Burling K, Wattler S, Russ A, Yeo GS, Chatterjee VK, O'Rahilly S, Voshol PJ, Cinti S, Vidal-Puig A. Gray SL, et al. Diabetes. 2006 Oct;55(10):2669-77. doi: 10.2337/db06-0389. Diabetes. 2006. PMID: 17003330

6

Genetics of obesity in humans.

Farooqi S, O'Rahilly S. Farooqi S, et al. Endocr Rev. 2006 Dec;27(7):710-18. doi: 10.1210/er.2006-0040. Epub 2006 Nov 22. Endocr Rev. 2006. PMID: 17122358 Review.

7

Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene.

Gray J, Yeo GS, Cox JJ, Morton J, Adlam AL, Keogh JM, Yanovski JA, El Gharbawy A, Han JC, Tung YC, Hodges JR, Raymond FL, O'rahilly S, Farooqi IS. Gray J, et al. Diabetes. 2006 Dec;55(12):3366-71. doi: 10.2337/db06-0550. Diabetes. 2006. PMID: 17130481 Free PMC article.

8

Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation.

Heisler LK, Pronchuk N, Nonogaki K, Zhou L, Raber J, Tung L, Yeo GS, O'Rahilly S, Colmers WF, Elmquist JK, Tecott LH. Heisler LK, et al. J Neurosci. 2007 Jun 27;27(26):6956-64. doi: 10.1523/JNEUROSCI.2584-06.2007. J Neurosci. 2007. PMID: 17596444 Free PMC article.

9

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ. Gerken T, et al. Science. 2007 Nov 30;318(5855):1469-72. doi: 10.1126/science.1151710. Epub 2007 Nov 8. Science. 2007. PMID: 17991826 Free PMC article.

10

Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors.

Lam DD, Przydzial MJ, Ridley SH, Yeo GS, Rochford JJ, O'Rahilly S, Heisler LK. Lam DD, et al. Endocrinology. 2008 Mar;149(3):1323-8. doi: 10.1210/en.2007-1321. Epub 2007 Nov 26. Endocrinology. 2008. PMID: 18039773 Free PMC article.

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