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Page 1
Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13.
Highfill SL, Rodriguez PC, Zhou Q, Goetz CA, Koehn BH, Veenstra R, Taylor PA, Panoskaltsis-Mortari A, Serody JS, Munn DH, Tolar J, Ochoa AC, Blazar BR. Highfill SL, et al. Blood. 2010 Dec 16;116(25):5738-47. doi: 10.1182/blood-2010-06-287839. Epub 2010 Aug 31. Blood. 2010. PMID: 20807889 Free PMC article.
Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality.
Saha A, Aoyama K, Taylor PA, Koehn BH, Veenstra RG, Panoskaltsis-Mortari A, Munn DH, Murphy WJ, Azuma M, Yagita H, Fife BT, Sayegh MH, Najafian N, Socie G, Ahmed R, Freeman GJ, Sharpe AH, Blazar BR. Saha A, et al. Blood. 2013 Oct 24;122(17):3062-73. doi: 10.1182/blood-2013-05-500801. Epub 2013 Sep 12. Blood. 2013. PMID: 24030385 Free PMC article.
The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease.
McDonald-Hyman C, Muller JT, Loschi M, Thangavelu G, Saha A, Kumari S, Reichenbach DK, Smith MJ, Zhang G, Koehn BH, Lin J, Mitchell JS, Fife BT, Panoskaltsis-Mortari A, Feser CJ, Kirchmeier AK, Osborn MJ, Hippen KL, Kelekar A, Serody JS, Turka LA, Munn DH, Chi H, Neubert TA, Dustin ML, Blazar BR. McDonald-Hyman C, et al. Among authors: koehn bh. J Clin Invest. 2018 Oct 1;128(10):4604-4621. doi: 10.1172/JCI95713. Epub 2018 Aug 14. J Clin Invest. 2018. PMID: 30106752 Free PMC article.
Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD.
Koehn BH, Saha A, McDonald-Hyman C, Loschi M, Thangavelu G, Ma L, Zaiken M, Dysthe J, Krepps W, Panthera J, Hippen K, Jameson SC, Miller JS, Cooper MA, Farady CJ, Iwawaki T, Ting JP, Serody JS, Murphy WJ, Hill GR, Murray PJ, Bronte V, Munn DH, Zeiser R, Blazar BR. Koehn BH, et al. Blood. 2019 Nov 7;134(19):1670-1682. doi: 10.1182/blood.2019001950. Blood. 2019. PMID: 31533918 Free PMC article.
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance.
ElTanbouly MA, Zhao Y, Nowak E, Li J, Schaafsma E, Le Mercier I, Ceeraz S, Lines JL, Peng C, Carriere C, Huang X, Day M, Koehn B, Lee SW, Silva Morales M, Hogquist KA, Jameson SC, Mueller D, Rothstein J, Blazar BR, Cheng C, Noelle RJ. ElTanbouly MA, et al. Among authors: koehn b. Science. 2020 Jan 17;367(6475):eaay0524. doi: 10.1126/science.aay0524. Science. 2020. PMID: 31949051 Free PMC article.
Dual JAK2/Aurora kinase A inhibition prevents human skin graft rejection by allo-inactivation and ILC2-mediated tissue repair.
Walton K, Walker K, Riddle M, Koehn BH, Reff J, Sagatys EM, Linden MA, Pidala J, Kim J, Lee MC, Kiluk JV, Hui JYC, Yun SY, Xing Y, Stefanski H, Lawrence HR, Lawrence NJ, Tolar J, Anasetti C, Blazar BR, Sebti SM, Betts BC. Walton K, et al. Among authors: koehn bh. Am J Transplant. 2022 Mar;22(3):717-730. doi: 10.1111/ajt.16870. Epub 2021 Nov 8. Am J Transplant. 2022. PMID: 34668635 Free PMC article.
Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo.
Ramos TL, Bolivar-Wagers S, Jin S, Thangavelu G, Simonetta F, Lin PY, Hirai T, Saha A, Koehn B, Su LL, Picton LK, Baker J, Lohmeyer JK, Riddle M, Eide C, Tolar J, Panoskaltsis-Mortari A, Wagner JE, Garcia KC, Negrin RS, Blazar BR. Ramos TL, et al. Among authors: koehn b. Blood. 2023 Mar 16;141(11):1337-1352. doi: 10.1182/blood.2022018440. Blood. 2023. PMID: 36564052 Free PMC article.
Enforced gut homing of murine regulatory T cells reduces early graft-versus-host disease severity.
Larson JH, Jin S, Loschi M, Bolivar Wagers S, Thangavelu G, Zaiken MC, McDonald-Hyman C, Saha A, Aguilar EG, Koehn B, Osborn MJ, Panoskaltsis-Mortari A, Macdonald KPA, Hill GR, Murphy WJ, Serody JS, Maillard I, Kean LS, Kim SV, Littman DR, Blazar BR. Larson JH, et al. Among authors: koehn b. Am J Transplant. 2023 Aug;23(8):1102-1115. doi: 10.1016/j.ajt.2023.01.030. Epub 2023 Mar 4. Am J Transplant. 2023. PMID: 36878433 Free PMC article.
29 results