Zinc lowers amyloid-beta toxicity by selectively precipitating aggregation intermediates.
Garai K, Sahoo B, Kaushalya SK, Desai R, Maiti S.
Garai K, et al. Among authors: sahoo b.
Biochemistry. 2007 Sep 18;46(37):10655-63. doi: 10.1021/bi700798b. Epub 2007 Aug 25.
Biochemistry. 2007.
PMID: 17718543
Zn2+ at a concentration of a few micromolar, which is too dilute to affect the precipitation equilibrium of Abeta, can destabilize these aggregates [Garai, K., Sengupta, P., Sahoo, B., and Maiti, S. (2006) Biochem. Biophys. Res. Commun. 345, 210-215]. Here we invest …
Zn2+ at a concentration of a few micromolar, which is too dilute to affect the precipitation equilibrium of Abeta, can destabilize these agg …