Opazo C - Search Results

1

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

Opazo C, Huang X, Cherny RA, Moir RD, Roher AE, White AR, Cappai R, Masters CL, Tanzi RE, Inestrosa NC, Bush AI. Opazo C, et al. J Biol Chem. 2002 Oct 25;277(43):40302-8. doi: 10.1074/jbc.M206428200. Epub 2002 Aug 20. J Biol Chem. 2002. PMID: 12192006 Free article.

2

Crosslinking of amyloid-beta peptide to brain acetylcholinesterase.

Opazo C, Inestrosa NC. Opazo C, et al. Mol Chem Neuropathol. 1998 Jan;33(1):39-49. doi: 10.1007/BF02815858. Mol Chem Neuropathol. 1998. PMID: 9493175

3

Amyloid-beta-peptide reduces copper(II) to copper(I) independent of its aggregation state.

Opazo C, Ruiz FH, Inestrosa NC. Opazo C, et al. Biol Res. 2000;33(2):125-31. doi: 10.4067/s0716-97602000000200012. Biol Res. 2000. PMID: 15693279

4

Copper reduction by copper binding proteins and its relation to neurodegenerative diseases.

Opazo C, Barría MI, Ruiz FH, Inestrosa NC. Opazo C, et al. Biometals. 2003 Mar;16(1):91-8. doi: 10.1023/a:1020795422185. Biometals. 2003. PMID: 12572668

5

The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo.

Cerpa WF, Barría MI, Chacón MA, Suazo M, González M, Opazo C, Bush AI, Inestrosa NC. Cerpa WF, et al. Among authors: opazo c. FASEB J. 2004 Nov;18(14):1701-3. doi: 10.1096/fj.03-1349fje. Epub 2004 Sep 2. FASEB J. 2004. PMID: 15345692

6

Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.

Puglielli L, Friedlich AL, Setchell KD, Nagano S, Opazo C, Cherny RA, Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI. Puglielli L, et al. Among authors: opazo c. J Clin Invest. 2005 Sep;115(9):2556-63. doi: 10.1172/JCI23610. Epub 2005 Aug 25. J Clin Invest. 2005. PMID: 16127459 Free PMC article.

7

Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification.

Minniti AN, Rebolledo DL, Grez PM, Fadic R, Aldunate R, Volitakis I, Cherny RA, Opazo C, Masters C, Bush AI, Inestrosa NC. Minniti AN, et al. Among authors: opazo c. Mol Neurodegener. 2009 Jan 6;4:2. doi: 10.1186/1750-1326-4-2. Mol Neurodegener. 2009. PMID: 19126228 Free PMC article.

8

Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure.

Parodi J, Sepúlveda FJ, Roa J, Opazo C, Inestrosa NC, Aguayo LG. Parodi J, et al. Among authors: opazo c. J Biol Chem. 2010 Jan 22;285(4):2506-14. doi: 10.1074/jbc.M109.030023. Epub 2009 Nov 13. J Biol Chem. 2010. PMID: 19915004 Free PMC article.

9

Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils.

Alvarez A, Opazo C, Alarcón R, Garrido J, Inestrosa NC. Alvarez A, et al. Among authors: opazo c. J Mol Biol. 1997 Sep 26;272(3):348-61. doi: 10.1006/jmbi.1997.1245. J Mol Biol. 1997. PMID: 9325095

10

Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils.

Alvarez A, Alarcón R, Opazo C, Campos EO, Muñoz FJ, Calderón FH, Dajas F, Gentry MK, Doctor BP, De Mello FG, Inestrosa NC. Alvarez A, et al. Among authors: opazo c. J Neurosci. 1998 May 1;18(9):3213-23. doi: 10.1523/JNEUROSCI.18-09-03213.1998. J Neurosci. 1998. PMID: 9547230 Free PMC article.

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