Dean TR - Search Results

1

Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist.

Hellberg MR, McLaughlin MA, Sharif NA, DeSantis L, Dean TR, Kyba EP, Bishop JE, Klimko PG, Zinke PW, Selliah RD, Barnes G, DeFaller J, Kothe A, Landry T, Sullivan EK, Andrew R, Davis AA, Silver L, Bergamini MV, Robertson S, Weiner AL, Sallee VL. Hellberg MR, et al. Among authors: dean tr. Surv Ophthalmol. 2002 Aug;47 Suppl 1:S13-33. doi: 10.1016/s0039-6257(02)00293-x. Surv Ophthalmol. 2002. PMID: 12204698

2

Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys.

May JA, McLaughlin MA, Sharif NA, Hellberg MR, Dean TR. May JA, et al. Among authors: dean tr. J Pharmacol Exp Ther. 2003 Jul;306(1):301-9. doi: 10.1124/jpet.103.049528. Epub 2003 Apr 3. J Pharmacol Exp Ther. 2003. PMID: 12676887

3

Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist.

Hellberg MR, Sallee VL, McLaughlin MA, Sharif NA, Desantis L, Dean TR, Zinke PW. Hellberg MR, et al. Among authors: dean tr. J Ocul Pharmacol Ther. 2001 Oct;17(5):421-32. doi: 10.1089/108076801753266802. J Ocul Pharmacol Ther. 2001. PMID: 11765147

4

Ocular Hypotensive Response in Nonhuman Primates of (8R)-1-[(2S)-2-Aminopropyl]-8,9-dihydro-7H-pyrano[2,3-g]indazol-8-ol a Selective 5-HT2 Receptor Agonist.

May JA, Sharif NA, McLaughlin MA, Chen HH, Severns BS, Kelly CR, Holt WF, Young R, Glennon RA, Hellberg MR, Dean TR. May JA, et al. Among authors: dean tr. J Med Chem. 2015 Nov 25;58(22):8818-33. doi: 10.1021/acs.jmedchem.5b00857. Epub 2015 Nov 9. J Med Chem. 2015. PMID: 26551970

5

The hydrolysis of the prostaglandin analog prodrug bimatoprost to 17-phenyl-trinor PGF2alpha by human and rabbit ocular tissue.

Hellberg MR, Ke TL, Haggard K, Klimko PG, Dean TR, Graff G. Hellberg MR, et al. Among authors: dean tr. J Ocul Pharmacol Ther. 2003 Apr;19(2):97-103. doi: 10.1089/108076803321637627. J Ocul Pharmacol Ther. 2003. PMID: 12804054

6

Increased optic nerve head blood flow after 1 week of twice daily topical brinzolamide treatment in Dutch-belted rabbits.

Barnes GE, Li B, Dean T, Chandler ML. Barnes GE, et al. Surv Ophthalmol. 2000 Jan;44 Suppl 2:S131-40. doi: 10.1016/s0039-6257(99)00124-1. Surv Ophthalmol. 2000. PMID: 10665515

7

2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit.

Chen HH, Gross S, Liao J, McLaughlin M, Dean T, Sly WS, May JA. Chen HH, et al. Bioorg Med Chem. 2000 May;8(5):957-75. doi: 10.1016/s0968-0896(00)00026-2. Bioorg Med Chem. 2000. PMID: 10882008

8

Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination.

Stams T, Chen Y, Boriack-Sjodin PA, Hurt JD, Liao J, May JA, Dean T, Laipis P, Silverman DN, Christianson DW. Stams T, et al. Protein Sci. 1998 Mar;7(3):556-63. doi: 10.1002/pro.5560070303. Protein Sci. 1998. PMID: 9541386 Free PMC article.

9

Structural analysis of inhibitor binding to human carbonic anhydrase II.

Boriack-Sjodin PA, Zeitlin S, Chen HH, Crenshaw L, Gross S, Dantanarayana A, Delgado P, May JA, Dean T, Christianson DW. Boriack-Sjodin PA, et al. Protein Sci. 1998 Dec;7(12):2483-9. doi: 10.1002/pro.5560071201. Protein Sci. 1998. PMID: 9865942 Free PMC article.

10

Aqueous humor dynamics in monkeys after topical R-DOI.

Gabelt BT, Okka M, Dean TR, Kaufman PL. Gabelt BT, et al. Among authors: dean tr. Invest Ophthalmol Vis Sci. 2005 Dec;46(12):4691-6. doi: 10.1167/iovs.05-0647. Invest Ophthalmol Vis Sci. 2005. PMID: 16303966

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