Chen E - Search Results

1

Discovery of a novel and potent class of FabI-directed antibacterial agents.

Payne DJ, Miller WH, Berry V, Brosky J, Burgess WJ, Chen E, DeWolf WE Jr, Fosberry AP, Greenwood R, Head MS, Heerding DA, Janson CA, Jaworski DD, Keller PM, Manley PJ, Moore TD, Newlander KA, Pearson S, Polizzi BJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Salyers KL, Seefeld MA, Smyth MG, Takata DT, Uzinskas IN, Vaidya K, Wallis NG, Winram SB, Yuan CC, Huffman WF. Payne DJ, et al. Among authors: chen e. Antimicrob Agents Chemother. 2002 Oct;46(10):3118-24. doi: 10.1128/AAC.46.10.3118-3124.2002. Antimicrob Agents Chemother. 2002. PMID: 12234833 Free PMC article.

2

Investigations of hydrazine cleavage of eltrombopag in humans.

Deng Y, Rogers M, Sychterz C, Talley K, Qian Y, Bershas D, Ho M, Shi W, Chen EP, Serabjit-Singh C, Gorycki PD. Deng Y, et al. Drug Metab Dispos. 2011 Sep;39(9):1747-54. doi: 10.1124/dmd.111.040188. Epub 2011 Jun 6. Drug Metab Dispos. 2011. PMID: 21646438

3

Enhancement of in vitro and in vivo microdialysis recovery of SB-265123 using Intralipid and Encapsin as perfusates.

Ward KW, Medina SJ, Portelli ST, Mahar Doan KM, Spengler MD, Ben MM, Lundberg D, Levy MA, Chen EP. Ward KW, et al. Biopharm Drug Dispos. 2003 Jan;24(1):17-25. doi: 10.1002/bdd.332. Biopharm Drug Dispos. 2003. PMID: 12516075

4

Model-based Target Pharmacology Assessment (mTPA): An Approach Using PBPK/PD Modeling and Machine Learning to Design Medicinal Chemistry and DMPK Strategies in Early Drug Discovery.

Chen EP, Bondi RW, Michalski PJ. Chen EP, et al. J Med Chem. 2021 Mar 25;64(6):3185-3196. doi: 10.1021/acs.jmedchem.0c02033. Epub 2021 Mar 15. J Med Chem. 2021. PMID: 33719432

5

Applications of Model-Based Target Pharmacology Assessment in Defining Drug Design and DMPK Strategies: GSK Experiences.

Chen EP, Bondi RW, Zhang C, Price DJ, Ho MH, Armacost KA, DeMartino MP. Chen EP, et al. J Med Chem. 2022 May 12;65(9):6926-6939. doi: 10.1021/acs.jmedchem.2c00330. Epub 2022 May 2. J Med Chem. 2022. PMID: 35500041

6

Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer.

Deng Y, Sychterz C, Suttle AB, Dar MM, Bershas D, Negash K, Qian Y, Chen EP, Gorycki PD, Ho MY. Deng Y, et al. Xenobiotica. 2013 May;43(5):443-53. doi: 10.3109/00498254.2012.734642. Epub 2012 Nov 16. Xenobiotica. 2013. PMID: 23548165 Clinical Trial.

7

Gastric pH and gastric residence time in fasted and fed conscious cynomolgus monkeys using the Bravo pH system.

Chen EP, Mahar Doan KM, Portelli S, Coatney R, Vaden V, Shi W. Chen EP, et al. Pharm Res. 2008 Jan;25(1):123-34. doi: 10.1007/s11095-007-9358-5. Epub 2007 Jul 6. Pharm Res. 2008. PMID: 17612796

8

A mechanism-based mathematical model of aryl hydrocarbon receptor-mediated CYP1A induction in rats using beta-naphthoflavone as a tool compound.

Chen EP, Chen L, Ji Y, Tai G, Wen YH, Ellens H. Chen EP, et al. Drug Metab Dispos. 2010 Dec;38(12):2278-85. doi: 10.1124/dmd.110.034421. Epub 2010 Sep 15. Drug Metab Dispos. 2010. PMID: 20843940

9

Gastric pH and gastric residence time in fasted and fed conscious beagle dogs using the Bravo pH system.

Mahar KM, Portelli S, Coatney R, Chen EP. Mahar KM, et al. J Pharm Sci. 2012 Jul;101(7):2439-48. doi: 10.1002/jps.23159. Epub 2012 Apr 24. J Pharm Sci. 2012. PMID: 22531871

10

The importance of villous physiology and morphology in mechanistic physiologically-based pharmacokinetic models.

Chen EP, Tai G, Ellens H. Chen EP, et al. Pharm Res. 2014 Feb;31(2):305-21. doi: 10.1007/s11095-013-1161-x. Epub 2013 Aug 30. Pharm Res. 2014. PMID: 23990312

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