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Synthesis and biological evaluation of disubstituted N6-cyclopentyladenine analogues: the search for a neutral antagonist with high affinity for the adenosine A1 receptor.
de Ligt RA, van der Klein PA, von Frijtag Drabbe Künzel JK, Lorenzen A, Ait El Maate F, Fujikawa S, van Westhoven R, van den Hoven T, Brussee J, IJzerman AP. de Ligt RA, et al. Bioorg Med Chem. 2004 Jan 2;12(1):139-49. doi: 10.1016/j.bmc.2003.10.023. Bioorg Med Chem. 2004. PMID: 14697779
Observational infant exploratory [(14)C]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis.
Garner CR, Park KB, French NS, Earnshaw C, Schipani A, Selby AM, Byrne L, Siner S, Crawley FP, Vaes WH, van Duijn E, deLigt R, Varendi H, Lass J, Grynkiewicz G, Maruszak W, Turner MA. Garner CR, et al. Br J Clin Pharmacol. 2015 Jul;80(1):157-67. doi: 10.1111/bcp.12597. Epub 2015 Jun 1. Br J Clin Pharmacol. 2015. PMID: 25619398 Free PMC article.
Microdosing of a Carbon-14 Labeled Protein in Healthy Volunteers Accurately Predicts Its Pharmacokinetics at Therapeutic Dosages.
Vlaming ML, van Duijn E, Dillingh MR, Brands R, Windhorst AD, Hendrikse NH, Bosgra S, Burggraaf J, de Koning MC, Fidder A, Mocking JA, Sandman H, de Ligt RA, Fabriek BO, Pasman WJ, Seinen W, Alves T, Carrondo M, Peixoto C, Peeters PA, Vaes WH. Vlaming ML, et al. Among authors: de ligt ra. Clin Pharmacol Ther. 2015 Aug;98(2):196-204. doi: 10.1002/cpt.131. Epub 2015 May 19. Clin Pharmacol Ther. 2015. PMID: 25869840 Clinical Trial.
Assessment of dermal absorption of aluminium from a representative antiperspirant formulation using a (26Al)Al microtracer approach: a follow-up study in humans.
de Ligt R, Westerhout J, Grossouw D, Buters TP, Rissmann R, Burggraaf J, Windhorst AD, Tozer S, Pappa G, Wall B, Bury D, Mason DR, Vaes WHJ. de Ligt R, et al. Toxicol Res (Camb). 2022 May 31;11(3):511-519. doi: 10.1093/toxres/tfac029. eCollection 2022 Jun. Toxicol Res (Camb). 2022. PMID: 35782644 Free PMC article.
15 results