Al-Abed Y - Search Results

1

Inhibition of HIV-1 nuclear import via schiff base formation with arylene bis(methylketone) compounds.

Al-Abed Y, Dubrovsky L, Ruzsicska B, Seepersaud M, Bukrinsky M. Al-Abed Y, et al. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3117-9. doi: 10.1016/s0960-894x(02)00642-x. Bioorg Med Chem Lett. 2002. PMID: 12372514

2

Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation.

Popov S, Dubrovsky L, Lee MA, Pennathur S, Haffar O, aL-Abed Y, Tonge P, Ulrich P, Rexach M, Blobel G, Cerami A, Bukrinsky M. Popov S, et al. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11859-64. doi: 10.1073/pnas.93.21.11859. Proc Natl Acad Sci U S A. 1996. PMID: 8876228 Free PMC article.

3

Identification of N2-(1-carboxymethyl)guanine (CMG) as a guanine advanced glycation end product.

al-Abed Y, Schleicher E, Voelter W, Liebich H, Papoulis A, Bucala R. al-Abed Y, et al. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2109-10. doi: 10.1016/s0960-894x(98)00398-9. Bioorg Med Chem Lett. 1998. PMID: 9873495

4

The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents.

Lubetsky JB, Dios A, Han J, Aljabari B, Ruzsicska B, Mitchell R, Lolis E, Al-Abed Y. Lubetsky JB, et al. J Biol Chem. 2002 Jul 12;277(28):24976-82. doi: 10.1074/jbc.M203220200. Epub 2002 May 7. J Biol Chem. 2002. PMID: 11997397 Free article.

5

Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity.

Dios A, Mitchell RA, Aljabari B, Lubetsky J, O'Connor K, Liao H, Senter PD, Manogue KR, Lolis E, Metz C, Bucala R, Callaway DJ, Al-Abed Y. Dios A, et al. J Med Chem. 2002 Jun 6;45(12):2410-6. doi: 10.1021/jm010534q. J Med Chem. 2002. PMID: 12036350

6

Critical modifications of the ISO-1 scaffold improve its potent inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity.

Cheng KF, Al-Abed Y. Cheng KF, et al. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3376-9. doi: 10.1016/j.bmcl.2006.04.038. Epub 2006 May 6. Bioorg Med Chem Lett. 2006. PMID: 16682188

7

Phenolic hydrazones are potent inhibitors of macrophage migration inhibitory factor proinflammatory activity and survival improving agents in sepsis.

Dabideen DR, Cheng KF, Aljabari B, Miller EJ, Pavlov VA, Al-Abed Y. Dabideen DR, et al. J Med Chem. 2007 Apr 19;50(8):1993-7. doi: 10.1021/jm061477+. Epub 2007 Mar 27. J Med Chem. 2007. PMID: 17385848 Free PMC article.

8

A structural investigation of FISLE-412, a peptidomimetic compound derived from saquinavir that targets lupus autoantibodies.

He M, Cheng KF, VanPatten S, Bloom O, Diamond B, Al-Abed Y. He M, et al. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4725-4729. doi: 10.1016/j.bmcl.2017.08.070. Epub 2017 Sep 17. Bioorg Med Chem Lett. 2017. PMID: 28927788

9

Synthesis and pharmacological evaluation of pomalidomide derivatives useful for sickle cell disease treatment.

de Melo TRF, Dulmovits BM, Fernandes GFDS, de Souza CM, Lanaro C, He M, Al Abed Y, Chung MC, Blanc L, Costa FF, Dos Santos JL. de Melo TRF, et al. Bioorg Chem. 2021 Sep;114:105077. doi: 10.1016/j.bioorg.2021.105077. Epub 2021 Jun 10. Bioorg Chem. 2021. PMID: 34130111 Free PMC article.

10

ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis.

Al-Abed Y, Dabideen D, Aljabari B, Valster A, Messmer D, Ochani M, Tanovic M, Ochani K, Bacher M, Nicoletti F, Metz C, Pavlov VA, Miller EJ, Tracey KJ. Al-Abed Y, et al. J Biol Chem. 2005 Nov 4;280(44):36541-4. doi: 10.1074/jbc.C500243200. Epub 2005 Aug 22. J Biol Chem. 2005. PMID: 16115897 Free article.

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