Pope AJ - Search Results

1

The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.

Brown MJ, Carter PS, Fenwick AS, Fosberry AP, Hamprecht DW, Hibbs MJ, Jarvest RL, Mensah L, Milner PH, O'Hanlon PJ, Pope AJ, Richardson CM, West A, Witty DR. Brown MJ, et al. Among authors: pope aj. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3171-4. doi: 10.1016/s0960-894x(02)00604-2. Bioorg Med Chem Lett. 2002. PMID: 12372526

2

Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.

Jarvest RL, Berge JM, Berry V, Boyd HF, Brown MJ, Elder JS, Forrest AK, Fosberry AP, Gentry DR, Hibbs MJ, Jaworski DD, O'Hanlon PJ, Pope AJ, Rittenhouse S, Sheppard RJ, Slater-Radosti C, Worby A. Jarvest RL, et al. Among authors: pope aj. J Med Chem. 2002 May 9;45(10):1959-62. doi: 10.1021/jm025502x. J Med Chem. 2002. PMID: 11985462

3

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown P, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Pope AJ, Rittenhouse S. Jarvest RL, et al. Among authors: pope aj. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1265-8. doi: 10.1016/s0960-894x(03)00093-3. Bioorg Med Chem Lett. 2003. PMID: 12657260

4

Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex.

Jarvest RL, Berge JM, Houge-Frydrych CS, Janson C, Mensah LM, O'Hanlon PJ, Pope A, Saldanha A, Qiu X. Jarvest RL, et al. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2859-62. doi: 10.1016/s0960-894x(99)00488-6. Bioorg Med Chem Lett. 1999. PMID: 10522706

5

Characterization of isoleucyl-tRNA synthetase from Staphylococcus aureus. II. Mechanism of inhibition by reaction intermediate and pseudomonic acid analogues studied using transient and steady-state kinetics.

Pope AJ, Moore KJ, McVey M, Mensah L, Benson N, Osbourne N, Broom N, Brown MJ, O'Hanlon P. Pope AJ, et al. J Biol Chem. 1998 Nov 27;273(48):31691-701. doi: 10.1074/jbc.273.48.31691. J Biol Chem. 1998. PMID: 9822630 Free article.

6

Molecular recognition of tyrosinyl adenylate analogues by prokaryotic tyrosyl tRNA synthetases.

Brown P, Richardson CM, Mensah LM, O'Hanlon PJ, Osborne NF, Pope AJ, Walker G. Brown P, et al. Among authors: pope aj. Bioorg Med Chem. 1999 Nov;7(11):2473-85. doi: 10.1016/s0968-0896(99)00192-3. Bioorg Med Chem. 1999. PMID: 10632057

7

Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A.

Brown MJ, Mensah LM, Doyle ML, Broom NJ, Osbourne N, Forrest AK, Richardson CM, O'Hanlon PJ, Pope AJ. Brown MJ, et al. Among authors: pope aj. Biochemistry. 2000 May 23;39(20):6003-11. doi: 10.1021/bi000148v. Biochemistry. 2000. PMID: 10821672

8

Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383.

Berge JM, Copley RC, Eggleston DS, Hamprecht DW, Jarvest RL, Mensah LM, O'Hanlon PJ, Pope AJ. Berge JM, et al. Among authors: pope aj. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1811-4. doi: 10.1016/s0960-894x(00)00348-6. Bioorg Med Chem Lett. 2000. PMID: 10969974

9

Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases.

Forrest AK, Jarvest RL, Mensah LM, O'Hanlon PJ, Pope AJ, Sheppard RJ. Forrest AK, et al. Among authors: pope aj. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1871-4. doi: 10.1016/s0960-894x(00)00360-7. Bioorg Med Chem Lett. 2000. PMID: 10969988

10

Synthesis and activity of analogues of SB-219383: novel potent inhibitors of bacterial tyrosyl tRNA synthetase.

Berge JM, Broom NJ, Houge-Frydrych CS, Jarvest RL, Mensah L, McNair DJ, O'Hanlon PJ, Pope AJ, Rittenhouse S. Berge JM, et al. Among authors: pope aj. J Antibiot (Tokyo). 2000 Nov;53(11):1282-92. doi: 10.7164/antibiotics.53.1282. J Antibiot (Tokyo). 2000. PMID: 11213289 Free article.

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