Grubb JH - Search Results

1

Missense models [Gustm(E536A)Sly, Gustm(E536Q)Sly, and Gustm(L175F)Sly] of murine mucopolysaccharidosis type VII produced by targeted mutagenesis.

Tomatsu S, Orii KO, Vogler C, Grubb JH, Snella EM, Gutierrez MA, Dieter T, Sukegawa K, Orii T, Kondo N, Sly WS. Tomatsu S, et al. Among authors: grubb jh. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14982-7. doi: 10.1073/pnas.232570999. Epub 2002 Oct 28. Proc Natl Acad Sci U S A. 2002. PMID: 12403825 Free PMC article.

2

Transgene produces massive overexpression of human beta -glucuronidase in mice, lysosomal storage of enzyme, and strain-dependent tumors.

Vogler C, Galvin N, Levy B, Grubb J, Jiang J, Zhou XY, Sly WS. Vogler C, et al. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2669-73. doi: 10.1073/pnas.0437941100. Epub 2003 Feb 18. Proc Natl Acad Sci U S A. 2003. PMID: 12591953 Free PMC article.

3

Production of MPS VII mouse (Gus(tm(hE540A x mE536A)Sly)) doubly tolerant to human and mouse beta-glucuronidase.

Tomatsu S, Orii KO, Vogler C, Grubb JH, Snella EM, Gutierrez M, Dieter T, Holden CC, Sukegawa K, Orii T, Kondo N, Sly WS. Tomatsu S, et al. Among authors: grubb jh. Hum Mol Genet. 2003 May 1;12(9):961-73. doi: 10.1093/hmg/ddg119. Hum Mol Genet. 2003. PMID: 12700165 Free PMC article.

4

Mouse model of N-acetylgalactosamine-6-sulfate sulfatase deficiency (Galns-/-) produced by targeted disruption of the gene defective in Morquio A disease.

Tomatsu S, Orii KO, Vogler C, Nakayama J, Levy B, Grubb JH, Gutierrez MA, Shim S, Yamaguchi S, Nishioka T, Montano AM, Noguchi A, Orii T, Kondo N, Sly WS. Tomatsu S, et al. Among authors: grubb jh. Hum Mol Genet. 2003 Dec 15;12(24):3349-58. doi: 10.1093/hmg/ddg366. Epub 2003 Oct 28. Hum Mol Genet. 2003. PMID: 14583446

5

Glycosylation-independent targeting enhances enzyme delivery to lysosomes and decreases storage in mucopolysaccharidosis type VII mice.

LeBowitz JH, Grubb JH, Maga JA, Schmiel DH, Vogler C, Sly WS. LeBowitz JH, et al. Among authors: grubb jh. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3083-8. doi: 10.1073/pnas.0308728100. Epub 2004 Feb 19. Proc Natl Acad Sci U S A. 2004. PMID: 14976248 Free PMC article.

6

Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier.

Urayama A, Grubb JH, Sly WS, Banks WA. Urayama A, et al. Among authors: grubb jh. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12658-63. doi: 10.1073/pnas.0405042101. Epub 2004 Aug 16. Proc Natl Acad Sci U S A. 2004. PMID: 15314220 Free PMC article.

7

Defining the pathway for Tat-mediated delivery of beta-glucuronidase in cultured cells and MPS VII mice.

Orii KO, Grubb JH, Vogler C, Levy B, Tan Y, Markova K, Davidson BL, Mao Q, Orii T, Kondo N, Sly WS. Orii KO, et al. Among authors: grubb jh. Mol Ther. 2005 Aug;12(2):345-52. doi: 10.1016/j.ymthe.2005.02.031. Mol Ther. 2005. PMID: 16043103 Free PMC article.

8

Overcoming the blood-brain barrier with high-dose enzyme replacement therapy in murine mucopolysaccharidosis VII.

Vogler C, Levy B, Grubb JH, Galvin N, Tan Y, Kakkis E, Pavloff N, Sly WS. Vogler C, et al. Among authors: grubb jh. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14777-82. doi: 10.1073/pnas.0506892102. Epub 2005 Sep 14. Proc Natl Acad Sci U S A. 2005. PMID: 16162667 Free PMC article.

9

Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors.

Sly WS, Vogler C, Grubb JH, Levy B, Galvin N, Tan Y, Nishioka T, Tomatsu S. Sly WS, et al. Among authors: grubb jh. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15172-7. doi: 10.1073/pnas.0607053103. Epub 2006 Oct 2. Proc Natl Acad Sci U S A. 2006. PMID: 17015822 Free PMC article.

10

Epinephrine enhances lysosomal enzyme delivery across the blood brain barrier by up-regulation of the mannose 6-phosphate receptor.

Urayama A, Grubb JH, Banks WA, Sly WS. Urayama A, et al. Among authors: grubb jh. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12873-8. doi: 10.1073/pnas.0705611104. Epub 2007 Jul 23. Proc Natl Acad Sci U S A. 2007. PMID: 17646643 Free PMC article.

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