Haouz A - Search Results

1

Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods.

Manallack DT, Pitt WR, Herdewijn P, Balzarini J, De Clercq E, Sanderson MR, Sohi M, Wien F, Munier-Lehmann H, Haouz A, Delarue M. Manallack DT, et al. Among authors: haouz a. J Enzyme Inhib Med Chem. 2002 Jun;17(3):167-74. doi: 10.1080/14756360290032949. J Enzyme Inhib Med Chem. 2002. PMID: 12443042 Free article.

2

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.

Haouz A, Vanheusden V, Munier-Lehmann H, Froeyen M, Herdewijn P, Van Calenbergh S, Delarue M. Haouz A, et al. J Biol Chem. 2003 Feb 14;278(7):4963-71. doi: 10.1074/jbc.M209630200. Epub 2002 Nov 25. J Biol Chem. 2003. PMID: 12454011 Free article.

3

Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway.

Fioravanti E, Haouz A, Ursby T, Munier-Lehmann H, Delarue M, Bourgeois D. Fioravanti E, et al. Among authors: haouz a. J Mol Biol. 2003 Apr 11;327(5):1077-92. doi: 10.1016/s0022-2836(03)00202-x. J Mol Biol. 2003. PMID: 12662932

4

The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.

Bellinzoni M, Haouz A, Graña M, Munier-Lehmann H, Shepard W, Alzari PM. Bellinzoni M, et al. Among authors: haouz a. Protein Sci. 2006 Jun;15(6):1489-93. doi: 10.1110/ps.062163406. Epub 2006 May 2. Protein Sci. 2006. PMID: 16672241 Free PMC article.

5

Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei.

Delarue M, Duclert-Savatier N, Miclet E, Haouz A, Giganti D, Ouazzani J, Lopez P, Nilges M, Stoven V. Delarue M, et al. Among authors: haouz a. J Mol Biol. 2007 Feb 23;366(3):868-81. doi: 10.1016/j.jmb.2006.11.063. Epub 2006 Nov 22. J Mol Biol. 2007. PMID: 17196981

6

First-in-class allosteric inhibitors of bacterial IMPDHs.

Alexandre T, Lupan A, Helynck O, Vichier-Guerre S, Dugué L, Gelin M, Haouz A, Labesse G, Munier-Lehmann H. Alexandre T, et al. Among authors: haouz a. Eur J Med Chem. 2019 Apr 1;167:124-132. doi: 10.1016/j.ejmech.2019.01.064. Epub 2019 Feb 2. Eur J Med Chem. 2019. PMID: 30769241 Free article.

7

Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel.

Nury H, Bocquet N, Le Poupon C, Raynal B, Haouz A, Corringer PJ, Delarue M. Nury H, et al. Among authors: haouz a. J Mol Biol. 2010 Feb 5;395(5):1114-27. doi: 10.1016/j.jmb.2009.11.024. Epub 2009 Nov 13. J Mol Biol. 2010. PMID: 19917292

8

Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation.

Labesse G, Alexandre T, Gelin M, Haouz A, Munier-Lehmann H. Labesse G, et al. Among authors: haouz a. Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1890-9. doi: 10.1107/S1399004715013115. Epub 2015 Aug 25. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26327379

9

Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.

Walter P, Mechaly A, Bous J, Haouz A, England P, Lai-Kee-Him J, Ancelin A, Hoos S, Baron B, Trapani S, Bron P, Labesse G, Munier-Lehmann H. Walter P, et al. Among authors: haouz a. FEBS J. 2022 Aug;289(16):4869-4887. doi: 10.1111/febs.16393. Epub 2022 Mar 9. FEBS J. 2022. PMID: 35152545 Free article.

10

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.

Sauguet L, Shahsavar A, Poitevin F, Huon C, Menny A, Nemecz À, Haouz A, Changeux JP, Corringer PJ, Delarue M. Sauguet L, et al. Among authors: haouz a. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):966-71. doi: 10.1073/pnas.1314997111. Epub 2013 Dec 23. Proc Natl Acad Sci U S A. 2014. PMID: 24367074 Free PMC article.

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